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Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction.

Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U.

Crit Care Med. 2007 Mar;35(3):886-92.


Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide.

Liang MD, Bagchi A, Warren HS, Tehan MM, Trigilio JA, Beasley-Topliffe LK, Tesini BL, Lazzaroni JC, Fenton MJ, Hellman J.

J Infect Dis. 2005 Mar 15;191(6):939-48. Epub 2005 Feb 8.


Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice.

Hellman J, Roberts JD Jr, Tehan MM, Allaire JE, Warren HS.

J Biol Chem. 2002 Apr 19;277(16):14274-80. Epub 2002 Feb 5.


Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation.

Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan YT, Prabhu SD.

Circulation. 2009 Mar 17;119(10):1386-97. doi: 10.1161/CIRCULATIONAHA.108.802918. Epub 2009 Mar 2.


Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2.

Mathur S, Walley KR, Wang Y, Indrambarya T, Boyd JH.

Circ J. 2011;75(10):2445-52. Epub 2011 Aug 4.


Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation.

Higashikuni Y, Tanaka K, Kato M, Nureki O, Hirata Y, Nagai R, Komuro I, Sata M.

J Am Heart Assoc. 2013 Nov 18;2(6):e000267. doi: 10.1161/JAHA.113.000267.


Passive immunization to outer membrane proteins MLP and PAL does not protect mice from sepsis.

Valentine CH, Hellman J, Beasley-Topliffe LK, Bagchi A, Warren HS.

Mol Med. 2006 Sep-Oct;12(9-10):252-8.


Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes.

Tian J, Guo X, Liu XM, Liu L, Weng QF, Dong SJ, Knowlton AA, Yuan WJ, Lin L.

Cardiovasc Res. 2013 Jun 1;98(3):391-401. doi: 10.1093/cvr/cvt047. Epub 2013 Feb 27.


Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.

Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, Li D, Chao W.

J Biol Chem. 2015 Oct 30;290(44):26688-98. doi: 10.1074/jbc.M115.661835. Epub 2015 Sep 11.


Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9.

Knuefermann P, Schwederski M, Velten M, Krings P, Ehrentraut H, Rüdiger M, Boehm O, Fink K, Dreiner U, Grohé C, Hoeft A, Baumgarten G, Koch A, Zacharowski K, Meyer R.

Cardiovasc Res. 2008 Apr 1;78(1):26-35. doi: 10.1093/cvr/cvn011. Epub 2008 Jan 14.


Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.

Romics L Jr, Dolganiuc A, Velayudham A, Kodys K, Mandrekar P, Golenbock D, Kurt-Jones E, Szabo G.

J Leukoc Biol. 2005 Dec;78(6):1255-64. Epub 2005 Oct 4.


MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes.

Zhu X, Zhao H, Graveline AR, Buys ES, Schmidt U, Bloch KD, Rosenzweig A, Chao W.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1900-9. Epub 2006 Apr 28.


The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.

Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G.

Hepatology. 2008 Oct;48(4):1224-31. doi: 10.1002/hep.22470.


Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis.

Zou L, Feng Y, Chen YJ, Si R, Shen S, Zhou Q, Ichinose F, Scherrer-Crosbie M, Chao W.

Crit Care Med. 2010 May;38(5):1335-42. doi: 10.1097/CCM.0b013e3181d99e67.


Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.

Mancuso G, Midiri A, Beninati C, Biondo C, Galbo R, Akira S, Henneke P, Golenbock D, Teti G.

J Immunol. 2004 May 15;172(10):6324-9.


Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response.

Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR.

Cardiovasc Res. 2006 Dec 1;72(3):384-93. Epub 2006 Sep 23.


Macrophage-elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88-dependent TNF-α production.

Delpino MV, Barrionuevo P, Macedo GC, Oliveira SC, Genaro SD, Scian R, Miraglia MC, Fossati CA, Baldi PC, Giambartolomei GH.

J Leukoc Biol. 2012 Feb;91(2):285-98. doi: 10.1189/jlb.04111185. Epub 2011 Nov 10.


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