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Items: 1 to 20 of 91

1.

Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor.

Yasuda S, Kai M, Imai S, Kanoh H, Sakane F.

FEBS Lett. 2007 Feb 6;581(3):551-7. Epub 2007 Jan 18.

3.

Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.

Tsushima S, Kai M, Yamada K, Imai S, Houkin K, Kanoh H, Sakane F.

J Biol Chem. 2004 Jul 2;279(27):28603-13. Epub 2004 Apr 21.

4.

Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells.

Siliceo M, García-Bernal D, Carrasco S, Díaz-Flores E, Coluccio Leskow F, Teixidó J, Kazanietz MG, Mérida I.

J Cell Sci. 2006 Jan 1;119(Pt 1):141-52. Epub 2005 Dec 13. Erratum in: J Cell Sci. 2006 Jan 15;119(Pt 2):388. Leskow, Federico C [corrected to Coluccio Leskow, Federico].

6.

Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling.

Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG.

EMBO J. 2006 May 17;25(10):2062-74. Epub 2006 Apr 20.

7.

Inhibition of aggressiveness of metastatic mouse mammary carcinoma cells by the beta2-chimaerin GAP domain.

Menna PL, Skilton G, Leskow FC, Alonso DF, Gomez DE, Kazanietz MG.

Cancer Res. 2003 May 1;63(9):2284-91.

8.

Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.

Kai M, Yasuda S, Imai S, Kanoh H, Sakane F.

Biochim Biophys Acta. 2007 Sep;1773(9):1407-15. Epub 2007 May 13.

9.

Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.

Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH.

Cell. 2004 Oct 29;119(3):407-18.

10.
11.

Subtype-specific translocation of diacylglycerol kinase alpha and gamma and its correlation with protein kinase C.

Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N, Saito N.

J Biol Chem. 2000 Aug 11;275(32):24760-6.

12.

Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.

Gutierrez-Uzquiza A, Colon-Gonzalez F, Leonard TA, Canagarajah BJ, Wang H, Mayer BJ, Hurley JH, Kazanietz MG.

Nat Commun. 2013;4:1849. doi: 10.1038/ncomms2834.

13.

Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleus.

Matsubara T, Shirai Y, Miyasaka K, Murakami T, Yamaguchi Y, Ueyama T, Kai M, Sakane F, Kanoh H, Hashimoto T, Kamada S, Kikkawa U, Saito N.

J Biol Chem. 2006 Mar 10;281(10):6152-64. Epub 2005 Dec 30.

14.

Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters.

Caloca MJ, Fernandez N, Lewin NE, Ching D, Modali R, Blumberg PM, Kazanietz MG.

J Biol Chem. 1997 Oct 17;272(42):26488-96.

15.

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration.

Dise RS, Frey MR, Whitehead RH, Polk DB.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G276-85. Epub 2007 Nov 8.

16.

Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor.

Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG.

J Biol Chem. 2001 May 25;276(21):18303-12. Epub 2001 Feb 14.

17.

Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.

Yang C, Klein EA, Assoian RK, Kazanietz MG.

Biochem J. 2008 Feb 15;410(1):167-75.

PMID:
17941827
18.

The lipid second messenger diacylglycerol as a negative regulator of Rac signalling.

Wang H, Kazanietz MG.

Biochem Soc Trans. 2006 Nov;34(Pt 5):855-7.

PMID:
17052214
19.

A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.

Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG.

J Biol Chem. 2010 May 28;285(22):16931-41. doi: 10.1074/jbc.M109.099036. Epub 2010 Mar 24.

20.

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