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FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta.

Shioi J, Georgakopoulos A, Mehta P, Kouchi Z, Litterst CM, Baki L, Robakis NK.

J Neurochem. 2007 May;101(3):674-81. Epub 2007 Jan 24.


Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.


Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

J Neurosci. 2007 Nov 28;27(48):13092-7.


Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease.

Antequera D, Vargas T, Ugalde C, Spuch C, Molina JA, Ferrer I, Bermejo-Pareja F, Carro E.

Neurobiol Dis. 2009 Oct;36(1):42-50. doi: 10.1016/j.nbd.2009.06.018. Epub 2009 Jul 14.


Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.

J Biol Chem. 2007 Aug 24;282(34):24504-13. Epub 2007 Jun 15.


Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.


Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.

Malik B, Currais A, Soriano S.

J Neurochem. 2008 Jul;106(2):912-6. doi: 10.1111/j.1471-4159.2008.05446.x. Epub 2008 May 2.


The presenilin 1 C92S mutation increases abeta 42 production.

Lewis PA, Perez-Tur J, Golde TE, Hardy J.

Biochem Biophys Res Commun. 2000 Oct 14;277(1):261-3.


Chinese Presenilin-1 V97L mutation enhanced Abeta42 levels in SH-SY5Y neuroblastoma cells.

Fang B, Jia L, Jia J.

Neurosci Lett. 2006 Oct 2;406(1-2):33-7. Epub 2006 Aug 17.


Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells.

Suga K, Saito A, Tomiyama T, Mori H, Akagawa K.

J Neurochem. 2005 Jul;94(2):425-39.


A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.

Flood DG, Lin YG, Lang DM, Trusko SP, Hirsch JD, Savage MJ, Scott RW, Howland DS.

Neurobiol Aging. 2009 Jul;30(7):1078-90. Epub 2007 Nov 28.


Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35.

Clementi ME, Pezzotti M, Orsini F, Sampaolese B, Mezzogori D, Grassi C, Giardina B, Misiti F.

Biochem Biophys Res Commun. 2006 Mar 31;342(1):206-13. Epub 2006 Feb 3.


Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.

Neurobiol Dis. 2007 Jul;27(1):102-7. Epub 2007 May 6.


Transplanted astrocytes internalize deposited beta-amyloid peptides in a transgenic mouse model of Alzheimer's disease.

Pihlaja R, Koistinaho J, Malm T, Sikkilä H, Vainio S, Koistinaho M.

Glia. 2008 Jan 15;56(2):154-63.


Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.

Biscaro B, Lindvall O, Hock C, Ekdahl CT, Nitsch RM.

J Neurosci. 2009 Nov 11;29(45):14108-19. doi: 10.1523/JNEUROSCI.2055-09.2009.


Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins.

Dorval V, Mazzella MJ, Mathews PM, Hay RT, Fraser PE.

Biochem J. 2007 Jun 1;404(2):309-16.


Beta-amyloid peptides stimulate endozepine biosynthesis in cultured rat astrocytes.

Tokay T, Masmoudi O, Gandolfo P, Leprince J, Pelletier G, Vaudry H, Tonon MC.

J Neurochem. 2005 Aug;94(3):607-16.


GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.


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