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Items: 1 to 20 of 155


NOTCH1-induced T-cell leukemia in transgenic zebrafish.

Chen J, Jette C, Kanki JP, Aster JC, Look AT, Griffin JD.

Leukemia. 2007 Mar;21(3):462-71. Epub 2007 Jan 25.


Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.

Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM.

Leukemia. 2012 Sep;26(9):2069-78. doi: 10.1038/leu.2012.116. Epub 2012 Apr 27.


NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis.

Forrester AM, Grabher C, McBride ER, Boyd ER, Vigerstad MH, Edgar A, Kai FB, Da'as SI, Payne E, Look AT, Berman JN.

Br J Haematol. 2011 Oct;155(2):167-81. doi: 10.1111/j.1365-2141.2011.08810.x. Epub 2011 Aug 2.


Myc-induced T cell leukemia in transgenic zebrafish.

Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT.

Science. 2003 Feb 7;299(5608):887-90.


CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors.

Palomero T, Barnes KC, Real PJ, Glade Bender JL, Sulis ML, Murty VV, Colovai AI, Balbin M, Ferrando AA.

Leukemia. 2006 Jul;20(7):1279-87. Epub 2006 May 11.


Cellular expression of antiapoptotic BCL-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia: a Children's Cancer Group Study.

Uckun FM, Yang Z, Sather H, Steinherz P, Nachman J, Bostrom B, Crotty L, Sarquis M, Ek O, Zeren T, Tubergen D, Reaman G, Gaynon P.

Blood. 1997 May 15;89(10):3769-77.


Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia.

Liu H, Chiang MY, Pear WS.

Int J Hematol. 2011 Aug;94(2):118-25. doi: 10.1007/s12185-011-0899-3. Epub 2011 Aug 5. Review.


The role of NOTCH1 signaling in T-ALL.

Ferrando AA.

Hematology Am Soc Hematol Educ Program. 2009:353-61. doi: 10.1182/asheducation-2009.1.353. Review.


NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis.

Göthert JR, Brake RL, Smeets M, Dührsen U, Begley CG, Izon DJ.

Blood. 2007 Nov 15;110(10):3753-62. Epub 2007 Aug 13.


Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.

Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT.

Cancer Cell. 2002 Feb;1(1):75-87.


Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

Langenau DM, Jette C, Berghmans S, Palomero T, Kanki JP, Kutok JL, Look AT.

Blood. 2005 Apr 15;105(8):3278-85. Epub 2004 Dec 23.


In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J.

Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5.


OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1.

Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, Slape C, Aplan PD.

Cancer Res. 2005 Aug 15;65(16):7151-8.


The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia.

Palomero T, Dominguez M, Ferrando AA.

Cell Cycle. 2008 Apr 15;7(8):965-70. Epub 2008 Feb 19.


NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.

Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ.

Clin Cancer Res. 2006 May 15;12(10):3043-9. Erratum in: Clin Cancer Res. 2009 Feb 15;15(4):1506.


The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.

Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska CL, Cherian C, Devidas M, Linda SB, Taub JW, Matherly LH.

Leukemia. 2009 Aug;23(8):1417-25. doi: 10.1038/leu.2009.64. Epub 2009 Apr 2.


Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.

van Grotel M, Meijerink JP, van Wering ER, Langerak AW, Beverloo HB, Buijs-Gladdines JG, Burger NB, Passier M, van Lieshout EM, Kamps WA, Veerman AJ, van Noesel MM, Pieters R.

Leukemia. 2008 Jan;22(1):124-31. Epub 2007 Oct 11.


Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently.

Priceputu E, Bouallaga I, Zhang Y, Li X, Chrobak P, Hanna ZS, Poudrier J, Kay DG, Jolicoeur P.

J Immunol. 2006 Aug 15;177(4):2153-66.


Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.

Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J.

J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14. Erratum in: J Biol Chem. 2013 Dec 27;288(52):37368.

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