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Items: 1 to 20 of 432

1.

Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.

St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ.

J Neurochem. 2007 Mar;100(6):1449-57.

2.

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.

Oliveras-Salvá M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D'Hooge R, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2013 Nov 25;8:44. doi: 10.1186/1750-1326-8-44.

3.

Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.

Gründemann J, Schlaudraff F, Haeckel O, Liss B.

Nucleic Acids Res. 2008 Apr;36(7):e38. doi: 10.1093/nar/gkn084.

5.

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

Vila M, Vukosavic S, Jackson-Lewis V, Neystat M, Jakowec M, Przedborski S.

J Neurochem. 2000 Feb;74(2):721-9.

6.

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates.

Purisai MG, McCormack AL, Langston WJ, Johnston LC, Di Monte DA.

Neurobiol Dis. 2005 Dec;20(3):898-906.

PMID:
16006134
7.

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.

Garcia-Reitboeck P, Anichtchik O, Dalley JW, Ninkina N, Tofaris GK, Buchman VL, Spillantini MG.

Exp Neurol. 2013 Oct;248:541-5. doi: 10.1016/j.expneurol.2013.07.015.

8.

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Björklund A.

J Neurosci. 2002 Apr 1;22(7):2780-91.

9.

Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects.

Khodr CE, Becerra A, Han Y, Bohn MC.

Brain Res. 2014 Mar 6;1550:47-60. doi: 10.1016/j.brainres.2014.01.010.

10.

Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons.

Ulusoy A, Björklund T, Buck K, Kirik D.

Neurobiol Dis. 2012 Sep;47(3):367-77. doi: 10.1016/j.nbd.2012.05.012.

PMID:
22659302
11.

Decreased alpha-synuclein expression in the aging mouse substantia nigra.

Mak SK, McCormack AL, Langston JW, Kordower JH, Di Monte DA.

Exp Neurol. 2009 Dec;220(2):359-65. doi: 10.1016/j.expneurol.2009.09.021.

PMID:
19800328
12.

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.

Ulusoy A, Febbraro F, Jensen PH, Kirik D, Romero-Ramos M.

Eur J Neurosci. 2010 Aug;32(3):409-22. doi: 10.1111/j.1460-9568.2010.07284.x.

PMID:
20704592
13.

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.

Bourdenx M, Dovero S, Engeln M, Bido S, Bastide MF, Dutheil N, Vollenweider I, Baud L, Piron C, Grouthier V, Boraud T, Porras G, Li Q, Baekelandt V, Scheller D, Michel A, Fernagut PO, Georges F, Courtine G, Bezard E, Dehay B.

Acta Neuropathol Commun. 2015 Jul 25;3:46. doi: 10.1186/s40478-015-0222-2.

15.

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

Halliday GM, Ophof A, Broe M, Jensen PH, Kettle E, Fedorow H, Cartwright MI, Griffiths FM, Shepherd CE, Double KL.

Brain. 2005 Nov;128(Pt 11):2654-64.

PMID:
16000336
16.

Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.

Mosharov EV, Larsen KE, Kanter E, Phillips KA, Wilson K, Schmitz Y, Krantz DE, Kobayashi K, Edwards RH, Sulzer D.

Neuron. 2009 Apr 30;62(2):218-29. doi: 10.1016/j.neuron.2009.01.033.

17.

Heat shock protein 70 reduces α-synuclein-induced predegenerative neuronal dystrophy in the α-synuclein viral gene transfer rat model of Parkinson's disease.

Moloney TC, Hyland R, O'Toole D, Paucard A, Kirik D, O'Doherty A, Gorman AM, Dowd E.

CNS Neurosci Ther. 2014 Jan;20(1):50-8. doi: 10.1111/cns.12200.

PMID:
24279716
18.

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.

Richter F, Gao F, Medvedeva V, Lee P, Bove N, Fleming SM, Michaud M, Lemesre V, Patassini S, De La Rosa K, Mulligan CK, Sioshansi PC, Zhu C, Coppola G, Bordet T, Pruss RM, Chesselet MF.

Neurobiol Dis. 2014 Sep;69:263-75. doi: 10.1016/j.nbd.2014.05.012.

19.

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression.

Fernagut PO, Hutson CB, Fleming SM, Tetreaut NA, Salcedo J, Masliah E, Chesselet MF.

Synapse. 2007 Dec;61(12):991-1001.

20.

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.

Van Rompuy AS, Oliveras-Salvá M, Van der Perren A, Corti O, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2015 Jun 23;10:23. doi: 10.1186/s13024-015-0017-8.

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