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Items: 1 to 20 of 111

1.

Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.

Huang DT, Hunt HW, Zhuang M, Ohi MD, Holton JM, Schulman BA.

Nature. 2007 Jan 25;445(7126):394-8. Epub 2007 Jan 14.

2.

Structural dissection of a gating mechanism preventing misactivation of ubiquitin by NEDD8's E1.

Souphron J, Waddell MB, Paydar A, Tokgöz-Gromley Z, Roussel MF, Schulman BA.

Biochemistry. 2008 Aug 26;47(34):8961-9. doi: 10.1021/bi800604c. Epub 2008 Jul 25.

3.

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL Jr, Holton JM, Schulman BA.

Mol Cell. 2003 Dec;12(6):1427-37.

4.

Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.

Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA.

Mol Cell. 2005 Feb 4;17(3):341-50.

5.

A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.

Huang DT, Miller DW, Mathew R, Cassell R, Holton JM, Roussel MF, Schulman BA.

Nat Struct Mol Biol. 2004 Oct;11(10):927-35. Epub 2004 Sep 7.

6.

Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.

Huang DT, Zhuang M, Ayrault O, Schulman BA.

Nat Struct Mol Biol. 2008 Mar;15(3):280-7. doi: 10.1038/nsmb.1387. Epub 2008 Feb 10.

PMID:
18264111
7.

Specific substrate recognition and thioester intermediate determinations in ubiquitin and SUMO conjugation cascades revealed by a high-sensitive FRET assay.

Jiang L, Saavedra AN, Way G, Alanis J, Kung R, Li J, Xiang W, Liao J.

Mol Biosyst. 2014 Apr;10(4):778-86. doi: 10.1039/c3mb70155g. Epub 2014 Jan 23.

PMID:
24452848
8.

Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.

Lv Z, Yuan L, Atkison JH, Aldana-Masangkay G, Chen Y, Olsen SK.

J Biol Chem. 2017 Jul 21;292(29):12089-12099. doi: 10.1074/jbc.M117.787622. Epub 2017 Jun 1.

PMID:
28572513
9.

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

Walden H, Podgorski MS, Schulman BA.

Nature. 2003 Mar 20;422(6929):330-4.

PMID:
12646924
10.

Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.

Wang J, Taherbhoy AM, Hunt HW, Seyedin SN, Miller DW, Miller DJ, Huang DT, Schulman BA.

PLoS One. 2010 Dec 30;5(12):e15805. doi: 10.1371/journal.pone.0015805.

11.

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.

Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA.

Cell. 2014 Jun 19;157(7):1671-84. doi: 10.1016/j.cell.2014.04.037.

12.
13.

Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.

Olsen SK, Lima CD.

Mol Cell. 2013 Mar 7;49(5):884-96. doi: 10.1016/j.molcel.2013.01.013. Epub 2013 Feb 14.

14.

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1.

Kaiser SE, Qiu Y, Coats JE, Mao K, Klionsky DJ, Schulman BA.

Autophagy. 2013 May;9(5):778-80. doi: 10.4161/auto.23644. Epub 2013 Feb 6.

15.

The basis for selective E1-E2 interactions in the ISG15 conjugation system.

Durfee LA, Kelley ML, Huibregtse JM.

J Biol Chem. 2008 Aug 29;283(35):23895-902. doi: 10.1074/jbc.M804069200. Epub 2008 Jun 26.

16.

Mechanism of E1-E2 interaction for the inhibition of Ubl adenylation.

Wang J, Cai S, Chen Y.

J Biol Chem. 2010 Oct 22;285(43):33457-62. doi: 10.1074/jbc.M110.135582. Epub 2010 Aug 3.

17.

Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.

Lee I, Schindelin H.

Cell. 2008 Jul 25;134(2):268-78. doi: 10.1016/j.cell.2008.05.046.

18.
19.

Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme.

Bacik JP, Walker JR, Ali M, Schimmer AD, Dhe-Paganon S.

J Biol Chem. 2010 Jun 25;285(26):20273-80. doi: 10.1074/jbc.M110.102921. Epub 2010 Apr 5.

20.

Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.

Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE.

Protein Sci. 2013 Dec;22(12):1691-7. doi: 10.1002/pro.2381.

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