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Items: 1 to 20 of 87

2.

Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.

Levitt PS, Liu H, Manning C, Weiss RS.

Genomics. 2005 Aug;86(2):212-24.

PMID:
15919177
3.

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

Levitt PS, Zhu M, Cassano A, Yazinski SA, Liu H, Darfler J, Peters RM, Weiss RS.

Mol Cell Biol. 2007 Mar;27(6):2189-201. Epub 2007 Jan 12.

4.
5.

Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.

Yazinski SA, Westcott PM, Ong K, Pinkas J, Peters RM, Weiss RS.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21282-7. doi: 10.1073/pnas.0904965106. Epub 2009 Nov 16.

6.

p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency.

Ghule PN, Xie RL, Colby JL, Jones SN, Lian JB, Wijnen AJ, Stein JL, Stein GS.

Cell Cycle. 2015 Aug 3;14(15):2501-8. doi: 10.1080/15384101.2015.1049783. Epub 2015 Jun 1.

7.

Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.

Melton DW, Ketchen AM, Núñez F, Bonatti-Abbondandolo S, Abbondandolo A, Squires S, Johnson RT.

J Cell Sci. 1998 Feb;111 ( Pt 3):395-404.

8.

Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.

Yun HJ, Hyun SK, Park JH, Kim BW, Kwon HJ.

Mol Cell Biochem. 2012 Apr;363(1-2):281-9. doi: 10.1007/s11010-011-1180-z. Epub 2011 Dec 11.

PMID:
22160829
9.

Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes.

Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z.

PLoS Genet. 2011 Sep;7(9):e1002291. doi: 10.1371/journal.pgen.1002291. Epub 2011 Sep 22.

10.

MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage.

Hsu HL, Choy CO, Kasiappan R, Shih HJ, Sawyer JR, Shu CL, Chu KL, Chen YR, Hsu HF, Gartenhaus RB.

DNA Repair (Amst). 2007 Sep 1;6(9):1319-32. Epub 2007 Apr 6.

PMID:
17416211
11.

An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.

Demuth I, Frappart PO, Hildebrand G, Melchers A, Lobitz S, Stöckl L, Varon R, Herceg Z, Sperling K, Wang ZQ, Digweed M.

Hum Mol Genet. 2004 Oct 15;13(20):2385-97. Epub 2004 Aug 27.

PMID:
15333589
12.

Components of DNA damage checkpoint pathway regulate UV exposure-dependent alterations of gene expression of FHIT and WWOX at chromosome fragile sites.

Ishii H, Mimori K, Inageta T, Murakumo Y, Vecchione A, Mori M, Furukawa Y.

Mol Cancer Res. 2005 Mar;3(3):130-8.

13.

Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.

Dodge JE, Okano M, Dick F, Tsujimoto N, Chen T, Wang S, Ueda Y, Dyson N, Li E.

J Biol Chem. 2005 May 6;280(18):17986-91. Epub 2005 Mar 8.

14.

Molecular parameters of genome instability: roles of fragile genes at common fragile sites.

Pichiorri F, Ishii H, Okumura H, Trapasso F, Wang Y, Huebner K.

J Cell Biochem. 2008 Aug 1;104(5):1525-33. doi: 10.1002/jcb.21560. Review.

PMID:
18393361
15.

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation.

Jackson-Grusby L, Beard C, Possemato R, Tudor M, Fambrough D, Csankovszki G, Dausman J, Lee P, Wilson C, Lander E, Jaenisch R.

Nat Genet. 2001 Jan;27(1):31-9.

PMID:
11137995
16.

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein.

Bertrand P, Rouillard D, Boulet A, Levalois C, Soussi T, Lopez BS.

Oncogene. 1997 Mar 6;14(9):1117-22.

17.

Conditional inactivation of Brca1, p53 and Rb in mouse ovaries results in the development of leiomyosarcomas.

Clark-Knowles KV, Senterman MK, Collins O, Vanderhyden BC.

PLoS One. 2009 Dec 31;4(12):e8534. doi: 10.1371/journal.pone.0008534.

18.

Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis.

Yamamoto K, Nihrane A, Aglipay J, Sironi J, Arkin S, Lipton JM, Ouchi T, Liu JM.

Mol Med. 2008 Mar-Apr;14(3-4):167-74. doi: 10.2119/2007-00122.Yamamoto.

19.

Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.

Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM.

Mol Cell Biol. 2007 Feb;27(4):1425-32. Epub 2006 Dec 11.

20.

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia.

Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS.

Mol Cell Biol. 2003 Jan;23(1):359-69.

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