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Items: 1 to 20 of 61


A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.

Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI.

Genes Dev. 2007 Jan 1;21(1):55-9.


Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis.

Xu J, Wang M, Gao X, Hu B, Du Y, Zhou J, Tian X, Huang X.

PLoS One. 2011 Apr 11;6(4):e18763. doi: 10.1371/journal.pone.0018763.


Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells.

Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, Zhang P.

PLoS Biol. 2008 Jan;6(1):e15. doi: 10.1371/journal.pbio.0060015.


A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.

Shepard JL, Amatruda JF, Stern HM, Subramanian A, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Barut B, Freedman M, Lee C, Spitsbergen J, Neuberg D, Weber G, Golub TR, Glickman JN, Kutok JL, Aster JC, Zon LI.

Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13194-9. Epub 2005 Sep 6.


The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.

Pfaff KL, Straub CT, Chiang K, Bear DM, Zhou Y, Zon LI.

Mol Cell Biol. 2007 Aug;27(16):5887-97. Epub 2007 Jun 18.


Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants.

Pandey R, Heidmann S, Lehner CF.

J Cell Sci. 2005 Feb 15;118(Pt 4):733-42. Epub 2005 Jan 25.


Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish.

Zhao X, Zhao L, Tian T, Zhang Y, Tong J, Zheng X, Meng A.

J Biol Chem. 2010 Sep 3;285(36):27924-34. doi: 10.1074/jbc.M110.136077. Epub 2010 Jun 23.


Functional characterization of cohesin SMC3 and separase and their roles in the segregation of large and minichromosomes in Trypanosoma brucei.

Bessat M, Ersfeld K.

Mol Microbiol. 2009 Mar;71(6):1371-85. doi: 10.1111/j.1365-2958.2009.06611.x. Epub 2009 Feb 3. Erratum in: Mol Microbiol. 2014 May;92(4):900.


Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression.

Wirth KG, Wutz G, Kudo NR, Desdouets C, Zetterberg A, Taghybeeglu S, Seznec J, Ducos GM, Ricci R, Firnberg N, Peters JM, Nasmyth K.

J Cell Biol. 2006 Mar 13;172(6):847-60.


Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.

Mukherjee M, Ge G, Zhang N, Huang E, Nakamura LV, Minor M, Fofanov V, Rao PH, Herron A, Pati D.

PLoS One. 2011;6(7):e22167. doi: 10.1371/journal.pone.0022167. Epub 2011 Jul 25.


Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.

Poss KD, Nechiporuk A, Stringer KF, Lee C, Keating MT.

Genes Dev. 2004 Jul 1;18(13):1527-32.


Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.

Althoff F, Karess RE, Lehner CF.

Mol Biol Cell. 2012 Jun;23(12):2275-91. doi: 10.1091/mbc.E12-02-0117. Epub 2012 May 2.


Hormone-induced chromosomal instability in p53-null mammary epithelium.

Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D.

Cancer Res. 2004 Aug 15;64(16):5608-16.


Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.

Siomos MF, Badrinath A, Pasierbek P, Livingstone D, White J, Glotzer M, Nasmyth K.

Curr Biol. 2001 Nov 27;11(23):1825-35.


Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.

Kitagawa R, Rose AM.

Nat Cell Biol. 1999 Dec;1(8):514-21.


Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.

Sak A, Fegers I, Groneberg M, Stuschke M.

Cell Prolif. 2008 Aug;41(4):660-70. doi: 10.1111/j.1365-2184.2008.00540.x. Epub 2008 Jun 19.


Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos.

Jeong K, Jeong JY, Lee HO, Choi E, Lee H.

Dev Biol. 2010 Sep 1;345(1):34-48. doi: 10.1016/j.ydbio.2010.06.004. Epub 2010 Jun 8.


Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.

Holland AJ, Taylor SS.

J Cell Sci. 2006 Aug 15;119(Pt 16):3325-36. Epub 2006 Jul 25.

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