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Items: 1 to 20 of 185

1.
2.

Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.

Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.

Genes Dev. 2011 Nov 1;25(21):2291-305. doi: 10.1101/gad.173039.111.

3.

Nkx2.2 regulates beta-cell function in the mature islet.

Doyle MJ, Sussel L.

Diabetes. 2007 Aug;56(8):1999-2007. Epub 2007 Apr 24.

4.

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.

Kordowich S, Collombat P, Mansouri A, Serup P.

BMC Dev Biol. 2011 Aug 31;11:52. doi: 10.1186/1471-213X-11-52.

5.

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.

Chao CS, Loomis ZL, Lee JE, Sussel L.

Dev Biol. 2007 Dec 15;312(2):523-32. Epub 2007 Oct 5.

6.

Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.

Metzger DE, Liu C, Ziaie AS, Naji A, Zaret KS.

Diabetes. 2014 May;63(5):1804-16. doi: 10.2337/db13-0867. Epub 2014 Jan 31.

7.

Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.

Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L.

Mol Endocrinol. 2010 Feb;24(2):381-90. doi: 10.1210/me.2009-0360. Epub 2009 Dec 4.

8.

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.

Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L.

J Biol Chem. 2009 Nov 6;284(45):31236-48. doi: 10.1074/jbc.M109.048694. Epub 2009 Sep 15.

9.

Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.

Mastracci TL, Anderson KR, Papizan JB, Sussel L.

PLoS Genet. 2013;9(2):e1003278. doi: 10.1371/journal.pgen.1003278. Epub 2013 Feb 7.

10.

Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.

Hunter CS, Dixit S, Cohen T, Ediger B, Wilcox C, Ferreira M, Westphal H, Stein R, May CL.

Diabetes. 2013 Mar;62(3):875-86. doi: 10.2337/db12-0952. Epub 2012 Nov 27.

11.

Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.

Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2924-9. Epub 2004 Feb 17.

12.

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F.

Dev Dyn. 2005 Jul;233(3):946-53.

13.

Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts.

Pauls S, Zecchin E, Tiso N, Bortolussi M, Argenton F.

Dev Biol. 2007 Apr 15;304(2):875-90. Epub 2007 Jan 20.

14.

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

Development. 1998 Jun;125(12):2213-21.

15.

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and β-cell differentiation.

Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS.

Development. 2012 Apr;139(8):1447-56. doi: 10.1242/dev.072892.

16.

Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate.

Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8. doi: 10.1073/pnas.1303386110. Epub 2013 Aug 14.

17.
18.

The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.

Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L.

Development. 2011 Aug;138(15):3213-24. doi: 10.1242/dev.058693.

19.

MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R.

Diabetes. 2006 Feb;55(2):297-304.

20.

Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker.

Ahmad Z, Rafeeq M, Collombat P, Mansouri A.

PLoS One. 2015 Dec 11;10(12):e0144597. doi: 10.1371/journal.pone.0144597. eCollection 2015.

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