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Items: 1 to 20 of 105

1.

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells.

Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F.

J Biol Chem. 2007 Mar 23;282(12):8959-68.

2.

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

van der Horst G, Farih-Sips H, Löwik CW, Karperien M.

Bone. 2003 Dec;33(6):899-910.

PMID:
14678849
3.

Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.

Amantea CM, Kim WK, Meliton V, Tetradis S, Parhami F.

J Cell Biochem. 2008 Oct 1;105(2):424-36. doi: 10.1002/jcb.21840.

4.
5.

A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.

Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F.

J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213.

6.

Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat.

Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, Hahn TJ, Parhami F.

J Bone Miner Res. 2004 May;19(5):830-40.

7.

Oxysterol-induced osteoblastic differentiation of pluripotent mesenchymal cells is mediated through a PKC- and PKA-dependent pathway.

Richardson JA, Amantea CM, Kianmahd B, Tetradis S, Lieberman JR, Hahn TJ, Parhami F.

J Cell Biochem. 2007 Apr 1;100(5):1131-45.

PMID:
17031848
8.

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling.

Nedelcu D, Liu J, Xu Y, Jao C, Salic A.

Nat Chem Biol. 2013 Sep;9(9):557-64. doi: 10.1038/nchembio.1290.

9.

Metabolites in vertebrate Hedgehog signaling.

Roberg-Larsen H, Strand MF, Krauss S, Wilson SR.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):669-74. doi: 10.1016/j.bbrc.2014.01.087. Review.

PMID:
24486313
10.

Oxysterols are allosteric activators of the oncoprotein Smoothened.

Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R.

Nat Chem Biol. 2012 Jan 8;8(2):211-20. doi: 10.1038/nchembio.765.

11.

miR-326 is downstream of Sonic hedgehog signaling and regulates the expression of Gli2 and smoothened.

Jiang Z, Cushing L, Ai X, Lü J.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):273-83. doi: 10.1165/rcmb.2013-0127OC.

12.

Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.

Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA.

Proc Natl Acad Sci U S A. 2016 May 24;113(21). doi: 10.1073/pnas.1604984113.

13.

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Sinha S, Chen JK.

Nat Chem Biol. 2006 Jan;2(1):29-30.

PMID:
16408088
14.

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

Myers BR, Sever N, Chong YC, Kim J, Belani JD, Rychnovsky S, Bazan JF, Beachy PA.

Dev Cell. 2013 Aug 26;26(4):346-57. doi: 10.1016/j.devcel.2013.07.015.

15.

Different effects of anti-sonic hedgehog antibodies and the hedgehog pathway inhibitor cyclopamine on generation of dopaminergic neurons from neurospheres of mesencephalic precursors.

Parga JA, Rodriguez-Pallares J, Blanco V, Guerra MJ, Labandeira-Garcia JL.

Dev Dyn. 2008 Apr;237(4):909-17. doi: 10.1002/dvdy.21481.

16.

In vitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells.

Hokugo A, Sorice S, Yalom A, Lee JC, Li A, Zuk P, Jarrahy R.

Plast Reconstr Surg. 2013 Jul;132(1):70e-80e. doi: 10.1097/PRS.0b013e318290f460.

PMID:
23806956
17.

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

Kim WK, Meliton V, Tetradis S, Weinmaster G, Hahn TJ, Carlson M, Nelson SF, Parhami F.

J Bone Miner Res. 2010 Apr;25(4):782-95. doi: 10.1359/jbmr.091024.

18.

The hedgehog receptor patched is involved in cholesterol transport.

Bidet M, Joubert O, Lacombe B, Ciantar M, Nehmé R, Mollat P, Brétillon L, Faure H, Bittman R, Ruat M, Mus-Veteau I.

PLoS One. 2011;6(9):e23834. doi: 10.1371/journal.pone.0023834.

19.

Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.

Roudaut H, Traiffort E, Gorojankina T, Vincent L, Faure H, Schoenfelder A, Mann A, Manetti F, Solinas A, Taddei M, Ruat M.

Mol Pharmacol. 2011 Mar;79(3):453-60. doi: 10.1124/mol.110.069708.

20.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

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