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BRIT1/MCPH1: a guardian of genome and an enemy of tumors.

Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin SY.

Cell Cycle. 2006 Nov;5(22):2579-83. Epub 2006 Nov 15. Review.


BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.

Lin SY, Rai R, Li K, Xu ZX, Elledge SJ.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15105-9. Epub 2005 Oct 10.


Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression.

Lin SY, Liang Y, Li K.

Yonsei Med J. 2010 May;51(3):295-301. doi: 10.3349/ymj.2010.51.3.295. Review.


BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.

Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY.

Cancer Cell. 2006 Aug;10(2):145-57. Epub 2006 Jul 27.


BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.

Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K.

PLoS Genet. 2010 Jan 22;6(1):e1000826. doi: 10.1371/journal.pgen.1000826.


Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.

Xu X, Lee J, Stern DF.

J Biol Chem. 2004 Aug 13;279(33):34091-4. Epub 2004 Jun 25.


BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

Peng G, Yim EK, Dai H, Jackson AP, Burgt Iv, Pan MR, Hu R, Li K, Lin SY.

Nat Cell Biol. 2009 Jul;11(7):865-72. doi: 10.1038/ncb1895. Epub 2009 Jun 14.


Differential regulation of centrosome integrity by DNA damage response proteins.

Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, Lin SY.

Cell Cycle. 2008 Jul 15;7(14):2225-33. Epub 2008 May 14.


DNA damage checkpoint, damage repair, and genome stability.

Liu WF, Yu SS, Chen GJ, Li YZ.

Yi Chuan Xue Bao. 2006 May;33(5):381-90. Review.


BRIT1/MCPH1 expression in chronic myeloid leukemia and its regulation of the G2/M checkpoint.

Giallongo C, Tibullo D, La Cava P, Branca A, Parrinello N, Spina P, Stagno F, Conticello C, Chiarenza A, Vigneri P, Palumbo GA, Di Raimondo F.

Acta Haematol. 2011;126(4):205-10. doi: 10.1159/000329911. Epub 2011 Sep 16. Erratum in: Acta Haematol. 2011;126(4):210. Acta Haematol. 2012;127(2):80.


Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model.

Liang Y, Gao H, Lin SY, Goss JA, Du C, Li K.

Oncogene. 2015 Aug 13;34(33):4368-78. doi: 10.1038/onc.2014.367. Epub 2014 Nov 3.


Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.

Jeffers LJ, Coull BJ, Stack SJ, Morrison CG.

Oncogene. 2008 Jan 3;27(1):139-44. Epub 2007 Jun 25.


BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer.

Zhang B, Wang E, Dai H, Hu R, Liang Y, Li K, Wang G, Peng G, Lin SY.

Carcinogenesis. 2013 Oct;34(10):2271-80. doi: 10.1093/carcin/bgt190. Epub 2013 Jun 1.


DNA damage checkpoints and cancer.

Shimada M, Nakanishi M.

J Mol Histol. 2006 Sep;37(5-7):253-60. Epub 2006 Jul 14. Review.


Cell cycle checkpoint control mechanisms that can be disrupted in cancer.

Dash BC, El-Deiry WS.

Methods Mol Biol. 2004;280:99-161. Review.


Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.

Lou Z, Chini CC, Minter-Dykhouse K, Chen J.

J Biol Chem. 2003 Apr 18;278(16):13599-602. Epub 2003 Feb 27.


Genetic instability in cancer cells by impaired cell cycle checkpoints.

Nakanishi M, Shimada M, Niida H.

Cancer Sci. 2006 Oct;97(10):984-9. Epub 2006 Aug 22. Review.


BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution.

Deng CX.

Nucleic Acids Res. 2006 Mar 6;34(5):1416-26. Print 2006. Review.


BRCA1 and its toolbox for the maintenance of genome integrity.

Huen MS, Sy SM, Chen J.

Nat Rev Mol Cell Biol. 2010 Feb;11(2):138-48. doi: 10.1038/nrm2831. Epub 2009 Dec 23. Review.

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