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Items: 1 to 20 of 100

1.

A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified Hemoglobin (Hemospan) in patients undergoing major orthopedic surgery.

Olofsson C, Ahl T, Johansson T, Larsson S, Nellgård P, Ponzer S, Fagrell B, Przybelski R, Keipert P, Winslow N, Winslow RM.

Anesthesiology. 2006 Dec;105(6):1153-63.

PMID:
17122578
2.

A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan) administered to orthopaedic surgery patients with spinal anaesthesia.

Olofsson C, Nygårds EB, Ponzer S, Fagrell B, Przybelski R, Keipert PE, Winslow N, Winslow RM.

Transfus Med. 2008 Feb;18(1):28-39. doi: 10.1111/j.1365-3148.2007.00811.x.

PMID:
18279190
3.

Hemospan: design principles for a new class of oxygen therapeutic.

Vandegriff KD, Winslow RM.

Artif Organs. 2009 Feb;33(2):133-8. doi: 10.1111/j.1525-1594.2008.00697.x.

PMID:
19178457
4.

Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study.

Olofsson CI, Górecki AZ, Dirksen R, Kofranek I, Majewski JA, Mazurkiewicz T, Jahoda D, Fagrell B, Keipert PE, Hardiman YJ, Levy H; Study 6084 Clinical Investigators.

Anesthesiology. 2011 May;114(5):1048-63. doi: 10.1097/ALN.0b013e318215e198.

PMID:
21455059
5.

A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol.

Björkholm M, Fagrell B, Przybelski R, Winslow N, Young M, Winslow RM.

Haematologica. 2005 Apr;90(4):505-15.

7.

Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch.

Young MA, Lohman J, Malavalli A, Vandegriff KD, Winslow RM.

J Cardiothorac Vasc Anesth. 2009 Jun;23(3):339-47. doi: 10.1053/j.jvca.2008.08.006. Epub 2008 Oct 22.

PMID:
18948027
8.

Haemoglobin-based oxygen carriers: is the benefit worth the risk?

Mackenzie CF.

Br J Hosp Med (Lond). 2009 Jan;70(1):26-30.

PMID:
19357574
9.
10.

MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine.

Young MA, Riddez L, Kjellström BT, Bursell J, Winslow F, Lohman J, Winslow RM.

Crit Care Med. 2005 Aug;33(8):1794-804.

PMID:
16096458
11.

Cell-free oxygen carriers: scientific foundations, clinical development, and new directions.

Winslow RM.

Biochim Biophys Acta. 2008 Oct;1784(10):1382-6. doi: 10.1016/j.bbapap.2008.04.032. Epub 2008 May 21. Review.

PMID:
18555029
12.

Severe adverse events associated with hemoglobin based oxygen carriers: role of resuscitative fluids and liquid preserved RBC.

Robert Valeri C, Ragno G, Veech RL.

Transfus Apher Sci. 2008 Dec;39(3):205-11. doi: 10.1016/j.transci.2008.09.008. Epub 2008 Oct 31. Review.

PMID:
18951848
13.

HBOC-201 vasoactivity in a phase III clinical trial in orthopedic surgery subjects--extrapolation of potential risk for acute trauma trials.

Freilich D, Pearce LB, Pitman A, Greenburg G, Berzins M, Bebris L, Ahlers S, McCarron R.

J Trauma. 2009 Feb;66(2):365-76. doi: 10.1097/TA.0b013e3181820d5c.

PMID:
19204509
14.

Randomized trial of diaspirin cross-linked hemoglobin solution as an alternative to blood transfusion after cardiac surgery. The DCLHb Cardiac Surgery Trial Collaborative Group.

Lamy ML, Daily EK, Brichant JF, Larbuisson RP, Demeyere RH, Vandermeersch EA, Lehot JJ, Parsloe MR, Berridge JC, Sinclair CJ, Baron JF, Przybelski RJ.

Anesthesiology. 2000 Mar;92(3):646-56.

PMID:
10719942
15.

Blood substitutes as pharmacotherapies in clinical practice.

Jahr JS, Walker V, Manoochehri K.

Curr Opin Anaesthesiol. 2007 Aug;20(4):325-30. Review.

PMID:
17620840
16.

The use of bovine hemoglobin glutamer-250 (Hemopure) in surgical patients: results of a multicenter, randomized, single-blinded trial.

Sprung J, Kindscher JD, Wahr JA, Levy JH, Monk TG, Moritz MW, O'Hara PJ.

Anesth Analg. 2002 Apr;94(4):799-808, table of contents.

PMID:
11916776
17.

The effect of Trendelenburg position, lactated Ringer's solution and 6% hydroxyethyl starch solution on cardiac output after spinal anesthesia.

Zorko N, Kamenik M, Starc V.

Anesth Analg. 2009 Feb;108(2):655-9. doi: 10.1213/ane.0b013e31818ec9e5.

PMID:
19151304
18.

Interference in clinical chemistry assays by the hemoglobin-based oxygen carrier, Hemospan.

Cameron SJ, Gerhardt G, Engelstad M, Young MA, Norris EJ, Sokoll LJ.

Clin Biochem. 2009 Feb;42(3):221-4. doi: 10.1016/j.clinbiochem.2008.10.023. Epub 2008 Nov 11.

PMID:
19028481
19.

Bolus injection of Ringer's solution and dextran 1 kDa during induction of spinal anesthesia.

Ewaldsson CA, Hahn RG.

Acta Anaesthesiol Scand. 2005 Feb;49(2):152-9.

PMID:
15715614
20.

Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease.

Keipert PE; MP4CO-SCD-105 Study Investigators.

Adv Exp Med Biol. 2016;923:23-29. doi: 10.1007/978-3-319-38810-6_3.

PMID:
27526120

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