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Items: 1 to 20 of 103


A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?

Ingram CJ, Elamin MF, Mulcare CA, Weale ME, Tarekegn A, Raga TO, Bekele E, Elamin FM, Thomas MG, Bradman N, Swallow DM.

Hum Genet. 2007 Feb;120(6):779-88. Epub 2006 Nov 21.


Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group.

Ingram CJ, Raga TO, Tarekegn A, Browning SL, Elamin MF, Bekele E, Thomas MG, Weale ME, Bradman N, Swallow DM.

J Mol Evol. 2009 Dec;69(6):579-88. doi: 10.1007/s00239-009-9301-y. Epub 2009 Nov 24.


Lactose digestion and the evolutionary genetics of lactase persistence.

Ingram CJ, Mulcare CA, Itan Y, Thomas MG, Swallow DM.

Hum Genet. 2009 Jan;124(6):579-91. doi: 10.1007/s00439-008-0593-6. Epub 2008 Nov 26.


13915*G DNA polymorphism associated with lactase persistence in Africa interacts with Oct-1.

Olds LC, Ahn JK, Sibley E.

Hum Genet. 2011 Jan;129(1):111-3. doi: 10.1007/s00439-010-0898-0. Epub 2010 Oct 20.


The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.

Jensen TG, Liebert A, Lewinsky R, Swallow DM, Olsen J, Troelsen JT.

Hum Genet. 2011 Oct;130(4):483-93. doi: 10.1007/s00439-011-0966-0. Epub 2011 Feb 15.


The lactase gene -13910T allele can not predict the lactase-persistence phenotype in north China.

Sun HM, Qiao YD, Chen F, Xu LD, Bai J, Fu SB.

Asia Pac J Clin Nutr. 2007;16(4):598-601.


Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups.

Mattar R, Monteiro MS, Villares CA, Santos AF, Silva JM, Carrilho FJ.

Nutr J. 2009 Oct 2;8:46. doi: 10.1186/1475-2891-8-46.


Lactase persistence genotyping: rapid detection of seven sequence variants in a single tube with melting curve analyses.

Strand H, Sørensen LK, Ingebretsen OC.

Clin Chem Lab Med. 2014 Sep;52(9):1277-82. doi: 10.1515/cclm-2014-0123.


Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population.

Friedrich DC, Santos SE, Ribeiro-dos-Santos ÂK, Hutz MH.

PLoS One. 2012;7(9):e46520. doi: 10.1371/journal.pone.0046520. Epub 2012 Sep 28.


Lactase persistence alleles reveal partial East African ancestry of southern African Khoe pastoralists.

Breton G, Schlebusch CM, Lombard M, Sjödin P, Soodyall H, Jakobsson M.

Curr Biol. 2014 Apr 14;24(8):852-8. doi: 10.1016/j.cub.2014.02.041. Epub 2014 Apr 3.


Genetics of lactase persistence and lactose intolerance.

Swallow DM.

Annu Rev Genet. 2003;37:197-219. Review.


Frequency of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups.

Raz M, Sharon Y, Yerushalmi B, Birk R.

Gene. 2013 Apr 25;519(1):67-70. doi: 10.1016/j.gene.2013.01.049. Epub 2013 Feb 13.


T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.

Lewinsky RH, Jensen TG, Møller J, Stensballe A, Olsen J, Troelsen JT.

Hum Mol Genet. 2005 Dec 15;14(24):3945-53. Epub 2005 Nov 21.


Ancient DNA analysis reveals high frequency of European lactase persistence allele (T-13910) in medieval central europe.

Krüttli A, Bouwman A, Akgül G, Della Casa P, Rühli F, Warinner C.

PLoS One. 2014 Jan 23;9(1):e86251. doi: 10.1371/journal.pone.0086251. eCollection 2014.


Convergent adaptation of human lactase persistence in Africa and Europe.

Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P.

Nat Genet. 2007 Jan;39(1):31-40. Epub 2006 Dec 10.


The Frequency of the LCT*-13910C>T Polymorphism Associated with Lactase Persistence Diverges among Euro-Descendant Groups from Brazil.

Boschmann SE, Boldt AB, de Souza IR, Petzl-Erler ML, Messias-Reason IJ.

Med Princ Pract. 2016;25(1):18-20. doi: 10.1159/000440807. Epub 2015 Nov 14.


The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans.

Poulter M, Hollox E, Harvey CB, Mulcare C, Peuhkuri K, Kajander K, Sarner M, Korpela R, Swallow DM.

Ann Hum Genet. 2003 Jul;67(Pt 4):298-311. Erratum in: Ann Hum Genet. 2005 Jul;69(Pt 4):499.


The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans.

Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG.

Am J Hum Genet. 2004 Jun;74(6):1102-10. Epub 2004 Apr 20.


Lactase haplotype frequencies in Caucasians: association with the lactase persistence/non-persistence polymorphism.

Harvey CB, Hollox EJ, Poulter M, Wang Y, Rossi M, Auricchio S, Iqbal TH, Cooper BT, Barton R, Sarner M, Korpela R, Swallow DM.

Ann Hum Genet. 1998 May;62(Pt 3):215-23.


Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia.

Weiskirchen R, Tag CG, Mengsteab S, Gressner AM, Ingram CJ, Swallow DM.

Clin Chim Acta. 2007 Sep;384(1-2):93-8. Epub 2007 Jun 16.


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