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Items: 1 to 20 of 86

1.

Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways.

Wisner A, Dufour E, Messaoudi M, Nejdi A, Marcel A, Ungeheuer MN, Rougeot C.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17979-84. Epub 2006 Nov 13.

2.

Human opiorphin is a naturally occurring antidepressant acting selectively on enkephalin-dependent delta-opioid pathways.

Javelot H, Messaoudi M, Garnier S, Rougeot C.

J Physiol Pharmacol. 2010 Jun;61(3):355-62.

3.

Systemically active human opiorphin is a potent yet non-addictive analgesic without drug tolerance effects.

Rougeot C, Robert F, Menz L, Bisson JF, Messaoudi M.

J Physiol Pharmacol. 2010 Aug;61(4):483-90.

4.

Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.

Rougeot C, Messaoudi M, Hermitte V, Rigault AG, Blisnick T, Dugave C, Desor D, Rougeon F.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8549-54. Epub 2003 Jun 30.

5.

Human opiorphin: the lack of physiological dependence, tolerance to antinociceptive effects and abuse liability in laboratory mice.

Popik P, Kamysz E, Kreczko J, Wróbel M.

Behav Brain Res. 2010 Nov 12;213(1):88-93. doi: 10.1016/j.bbr.2010.04.045. Epub 2010 May 8.

PMID:
20438769
6.

STR-324, a Stable Analog of Opiorphin, Causes Analgesia in Postoperative Pain by Activating Endogenous Opioid Receptor-dependent Pathways.

Sitbon P, Van Elstraete A, Hamdi L, Juarez-Perez V, Mazoit JX, Benhamou D, Rougeot C.

Anesthesiology. 2016 Nov;125(5):1017-1029.

PMID:
27571257
7.

Transfer of opiorphin through a blood-brain barrier culture model.

Bocsik A, Darula Z, Tóth G, Deli MA, Wollemann M.

Arch Med Res. 2015 Aug;46(6):502-6. doi: 10.1016/j.arcmed.2015.06.009. Epub 2015 Jul 2.

PMID:
26143971
8.

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.

Schreiter A, Gore C, Labuz D, Fournie-Zaluski MC, Roques BP, Stein C, Machelska H.

FASEB J. 2012 Dec;26(12):5161-71. doi: 10.1096/fj.12-208678. Epub 2012 Aug 24.

PMID:
22923332
9.

[Identification of human opiorphin, a natural antinociceptive modulator of opioid-dependent pathways].

Rougeot C, Messaoudi M.

Med Sci (Paris). 2007 Jan;23(1):37-9. French. No abstract available.

10.

Effects and underlying mechanisms of human opiorphin on colonic motility and nociception in mice.

Tian XZ, Chen J, Xiong W, He T, Chen Q.

Peptides. 2009 Jul;30(7):1348-54. doi: 10.1016/j.peptides.2009.04.002. Epub 2009 Apr 10.

PMID:
19442408
11.

Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide.

Rosa M, Marcelo F, Calle LP, Rougeot C, Jiménez-Barbero J, Arsequell G, Valencia G.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5190-3. doi: 10.1016/j.bmcl.2015.09.071. Epub 2015 Oct 14.

PMID:
26463133
12.

Structure-activity relationship study of opiorphin, a human dual ectopeptidase inhibitor with antinociceptive properties.

Rosa M, Arsequell G, Rougeot C, Calle LP, Marcelo F, Pinto M, Centeno NB, Jiménez-Barbero J, Valencia G.

J Med Chem. 2012 Feb 9;55(3):1181-8. doi: 10.1021/jm2012112. Epub 2012 Jan 25.

PMID:
22224710
13.

Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum.

Kamysz E, Sałaga M, Sobczak M, Kamysz W, Fichna J.

J Pept Sci. 2013 Mar;19(3):166-72. doi: 10.1002/psc.2486. Epub 2013 Feb 4.

PMID:
23381913
14.

Opiorphin highly improves the specific binding and affinity of MERF and MEGY to rat brain opioid receptors.

Tóth F, Tóth G, Benyhe S, Rougeot C, Wollemann M.

Regul Pept. 2012 Oct 10;178(1-3):71-5. doi: 10.1016/j.regpep.2012.06.011. Epub 2012 Jul 4.

PMID:
22771829
15.

Effects of synthetic analogues of human opiorphin on rat brain opioid receptors.

Benyhe Z, Toth G, Wollemann M, Borsodi A, Helyes Z, Rougeot C, Benyhe S.

J Physiol Pharmacol. 2014 Aug;65(4):525-30.

16.

Opiorphin causes a panicolytic-like effect in rat panic models mediated by μ-opioid receptors in the dorsal periaqueductal gray.

Maraschin JC, Rangel MP, Bonfim AJ, Kitayama M, Graeff FG, Zangrossi H Jr, Audi EA.

Neuropharmacology. 2016 Feb;101:264-70. doi: 10.1016/j.neuropharm.2015.09.008. Epub 2015 Sep 10.

PMID:
26363194
17.

Enkephalinase inhibitors: potential agents for the management of pain.

Thanawala V, Kadam VJ, Ghosh R.

Curr Drug Targets. 2008 Oct;9(10):887-94. Review.

PMID:
18855623
19.

Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.

Chen H, Noble F, Mothé A, Meudal H, Coric P, Danascimento S, Roques BP, George P, Fournié-Zaluski MC.

J Med Chem. 2000 Apr 6;43(7):1398-408.

PMID:
10753476
20.

The Opiorphin Analog STR-324 Decreases Sensory Hypersensitivity in a Rat Model of Neuropathic Pain.

Van Elstraete A, Sitbon P, Hamdi L, Juarez-Perez V, Mazoit JX, Benhamou D, Rougeot C.

Anesth Analg. 2017 Aug 10. doi: 10.1213/ANE.0000000000002413. [Epub ahead of print]

PMID:
28806211

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