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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.

He YJ, McCall CM, Hu J, Zeng Y, Xiong Y.

Genes Dev. 2006 Nov 1;20(21):2949-54.


Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N.

Nature. 2006 Oct 5;443(7111):590-3.


Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases.

Lee JH, Terzaghi W, Gusmaroli G, Charron JB, Yoon HJ, Chen H, He YJ, Xiong Y, Deng XW.

Plant Cell. 2008 Jan;20(1):152-67. doi: 10.1105/tpc.107.055418.


WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y.

Genes Dev. 2008 Apr 1;22(7):866-71. doi: 10.1101/gad.1624008.


Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.

McCall CM, Miliani de Marval PL, Chastain PD 2nd, Jackson SC, He YJ, Kotake Y, Cook JG, Xiong Y.

Mol Cell Biol. 2008 Sep;28(18):5621-33. doi: 10.1128/MCB.00232-08.


CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H.

Nat Cell Biol. 2006 Nov;8(11):1277-83.


L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.

Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1719-29.


Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes.

Zhang Y, Feng S, Chen F, Chen H, Wang J, McCall C, Xiong Y, Deng XW.

Plant Cell. 2008 Jun;20(6):1437-55. doi: 10.1105/tpc.108.058891.


CRL4s: the CUL4-RING E3 ubiquitin ligases.

Jackson S, Xiong Y.

Trends Biochem Sci. 2009 Nov;34(11):562-70. doi: 10.1016/j.tibs.2009.07.002. Review.


Arabidopsis CULLIN4-damaged DNA binding protein 1 interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA complexes to regulate photomorphogenesis and flowering time.

Chen H, Huang X, Gusmaroli G, Terzaghi W, Lau OS, Yanagawa Y, Zhang Y, Li J, Lee JH, Zhu D, Deng XW.

Plant Cell. 2010 Jan;22(1):108-23. doi: 10.1105/tpc.109.065490.


VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.

Huang J, Chen J.

Oncogene. 2008 Jul 3;27(29):4056-64. doi: 10.1038/onc.2008.44.


Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.

Hu J, McCall CM, Ohta T, Xiong Y.

Nat Cell Biol. 2004 Oct;6(10):1003-9.


A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.

Li T, Robert EI, van Breugel PC, Strubin M, Zheng N.

Nat Struct Mol Biol. 2010 Jan;17(1):105-11. doi: 10.1038/nsmb.1719.


Defining the interactions and role of DCAF1/VPRBP in the DDB1-cullin4A E3 ubiquitin ligase complex engaged by HIV-1 Vpr to induce a G2 cell cycle arrest.

Gérard FC, Yang R, Romani B, Poisson A, Belzile JP, Rougeau N, Cohen ÉA.

PLoS One. 2014 Feb 18;9(2):e89195. doi: 10.1371/journal.pone.0089195.


Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.

Pick E, Lau OS, Tsuge T, Menon S, Tong Y, Dohmae N, Plafker SM, Deng XW, Wei N.

Mol Cell Biol. 2007 Jul;27(13):4708-19.


L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.

Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1675-80.


CRL4-DDB1-VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10.

Kaur M, Khan MM, Kar A, Sharma A, Saxena S.

Nucleic Acids Res. 2012 Aug;40(15):7332-46. doi: 10.1093/nar/gks366.


DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction.

Lee JH, Yoon HJ, Terzaghi W, Martinez C, Dai M, Li J, Byun MO, Deng XW.

Plant Cell. 2010 Jun;22(6):1716-32. doi: 10.1105/tpc.109.073783.

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