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Appl Opt. 2006 Oct 20;45(30):7938-43.

Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease.

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Tashiro Probing Technology Laboratory, RIKEN The Institute of Physical and Chemical Research, Hirosawa, Wako-shi, Saitama, Japan.


An intravascular catheter for Raman spectroscopic detection and analysis of coronary atherosclerotic disease has been developed. The catheter, having an outer diameter of 2 mm, consisted of a side-view-type micro-Raman probe, an imaging fiber bundle, a working channel (injection drain), and a balloon. By inflating the balloon, the probe was brought close to the inner wall of a modeled blood flow system and detected a phantom target buried in the wall. Results obtained demonstrate the possibility of using the spectroscopic catheter for molecular diagnosis of coronary lesions.

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