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Items: 1 to 20 of 115


DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.

Kundakovic M, Chen Y, Costa E, Grayson DR.

Mol Pharmacol. 2007 Mar;71(3):644-53. Epub 2006 Oct 25.


Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.

Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12578-83. Epub 2005 Aug 19.


The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Kundakovic M, Chen Y, Guidotti A, Grayson DR.

Mol Pharmacol. 2009 Feb;75(2):342-54. doi: 10.1124/mol.108.051763. Epub 2008 Nov 24.


DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.

Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, Grayson DR.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1749-54. Epub 2005 Jan 25.


DNA (cytosine-5) methyltransferase inhibitors: a potential therapeutic agent for schizophrenia.

Levenson JM.

Mol Pharmacol. 2007 Mar;71(3):635-7. Epub 2006 Dec 19.


An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.

Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17095-100. Epub 2002 Dec 12.


Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters.

Dong E, Guidotti A, Grayson DR, Costa E.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4676-81. Epub 2007 Mar 7.


Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A.

Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.


DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.

Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):348-53. Epub 2003 Dec 18.


DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A.

Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2.


The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.

Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP.

Pharmacol Ther. 2006 Jul;111(1):272-86. Epub 2006 Mar 30. Review.


In psychosis, cortical interneurons overexpress DNA-methyltransferase 1.

Veldic M, Guidotti A, Maloku E, Davis JM, Costa E.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2152-7. Epub 2005 Jan 31.


GABAergic dysfunction in mGlu7 receptor-deficient mice as reflected by decreased levels of glutamic acid decarboxylase 65 and 67kDa and increased reelin proteins in the hippocampus.

Wierońska JM, Brański P, Siwek A, Dybala M, Nowak G, Pilc A.

Brain Res. 2010 Jun 2;1334:12-24. doi: 10.1016/j.brainres.2010.03.078. Epub 2010 Mar 29.


Reelin promoter hypermethylation in schizophrenia.

Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, Costa E.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9341-6. Epub 2005 Jun 16.


Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.

Dong E, Nelson M, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13614-9. doi: 10.1073/pnas.0805493105. Epub 2008 Aug 29.


On the epigenetic regulation of the human reelin promoter.

Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR.

Nucleic Acids Res. 2002 Jul 1;30(13):2930-9.


S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis.

Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E.

Neuroreport. 2007 Jan 8;18(1):57-60.


Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum.

Zhubi A, Chen Y, Dong E, Cook EH, Guidotti A, Grayson DR.

Transl Psychiatry. 2014 Jan 21;4:e349. doi: 10.1038/tp.2013.123.


Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation.

Dong E, Grayson DR, Guidotti A, Costa E.

Epigenomics. 2009 Oct;1(1):201-11. doi: 10.2217/epi.09.2.


Histone deacetylase inhibitors decrease reelin promoter methylation in vitro.

Mitchell CP, Chen Y, Kundakovic M, Costa E, Grayson DR.

J Neurochem. 2005 Apr;93(2):483-92.

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