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Tolcapone improves cognition and cortical information processing in normal human subjects.

Apud JA, Mattay V, Chen J, Kolachana BS, Callicott JH, Rasetti R, Alce G, Iudicello JE, Akbar N, Egan MF, Goldberg TE, Weinberger DR.

Neuropsychopharmacology. 2007 May;32(5):1011-20. Epub 2006 Oct 25.


Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism.

Giakoumaki SG, Roussos P, Bitsios P.

Neuropsychopharmacology. 2008 Dec;33(13):3058-68. doi: 10.1038/npp.2008.82. Epub 2008 Jun 4.


Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study.

Ashare RL, Wileyto EP, Ruparel K, Goelz PM, Hopson RD, Valdez JN, Gur RC, Loughead J, Lerman C.

Drug Alcohol Depend. 2013 Dec 15;133(3):852-6. doi: 10.1016/j.drugalcdep.2013.09.003. Epub 2013 Sep 14.


A proof of concept study of tolcapone for pathological gambling: relationships with COMT genotype and brain activation.

Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, Kim SW.

Eur Neuropsychopharmacol. 2013 Nov;23(11):1587-96. doi: 10.1016/j.euroneuro.2013.07.008. Epub 2013 Aug 6.


COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition.

Farrell SM, Tunbridge EM, Braeutigam S, Harrison PJ.

Biol Psychiatry. 2012 Mar 15;71(6):538-44. doi: 10.1016/j.biopsych.2011.12.023. Erratum in: Biol Psychiatry. 2015 Feb 1;77(3):304.


Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex.

Lapish CC, Ahn S, Evangelista LM, So K, Seamans JK, Phillips AG.

Psychopharmacology (Berl). 2009 Jan;202(1-3):521-30. doi: 10.1007/s00213-008-1342-1. Epub 2008 Oct 15.


Effect of tolcapone on brain activity during a variable attentional control task: a double-blind, placebo-controlled, counter-balanced trial in healthy volunteers.

Magalona SC, Rasetti R, Chen J, Chen Q, Gold I, Decot H, Callicott JH, Berman KF, Apud JA, Weinberger DR, Mattay VS.

CNS Drugs. 2013 Aug;27(8):663-73. doi: 10.1007/s40263-013-0082-x.


Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism.

Roussos P, Giakoumaki SG, Bitsios P.

Biol Psychiatry. 2009 Dec 1;66(11):997-1004. doi: 10.1016/j.biopsych.2009.07.008. Epub 2009 Aug 22.


Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism.

Plewnia C, Zwissler B, Längst I, Maurer B, Giel K, Krüger R.

Cortex. 2013 Jul-Aug;49(7):1801-7. doi: 10.1016/j.cortex.2012.11.002. Epub 2012 Nov 15.


Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia.

Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR.

Arch Gen Psychiatry. 2003 Sep;60(9):889-96.


Dopamine, locus of control, and the exploration-exploitation tradeoff.

Kayser AS, Mitchell JM, Weinstein D, Frank MJ.

Neuropsychopharmacology. 2015 Jan;40(2):454-62. doi: 10.1038/npp.2014.193. Epub 2014 Jul 30.


Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.

Ettinger U, Kumari V, Collier DA, Powell J, Luzi S, Michel TM, Zedomi O, Williams SC.

Neuropsychopharmacology. 2008 Dec;33(13):3046-57. doi: 10.1038/sj.npp.1301658. Epub 2008 Jan 30.


Influence of COMT gene polymorphism on fMRI-assessed sustained and transient activity during a working memory task.

de Frias CM, Marklund P, Eriksson E, Larsson A, Oman L, Annerbrink K, Bäckman L, Nilsson LG, Nyberg L.

J Cogn Neurosci. 2010 Jul;22(7):1614-22. doi: 10.1162/jocn.2009.21318.


Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.

Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR, Nardini M.

Am J Psychiatry. 2004 Oct;161(10):1798-805.


Modulation of hippocampal dopamine metabolism and hippocampal-dependent cognitive function by catechol-O-methyltransferase inhibition.

Laatikainen LM, Sharp T, Bannerman DM, Harrison PJ, Tunbridge EM.

J Psychopharmacol. 2012 Dec;26(12):1561-8. doi: 10.1177/0269881112454228. Epub 2012 Jul 19.


Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity.

Ursini G, Bollati V, Fazio L, Porcelli A, Iacovelli L, Catalani A, Sinibaldi L, Gelao B, Romano R, Rampino A, Taurisano P, Mancini M, Di Giorgio A, Popolizio T, Baccarelli A, De Blasi A, Blasi G, Bertolino A.

J Neurosci. 2011 May 4;31(18):6692-8. doi: 10.1523/JNEUROSCI.6631-10.2011.


Catechol-O-methyltransferase val158met genotype modulates sustained attention in both the drug-free state and in response to amphetamine.

Hamidovic A, Dlugos A, Palmer AA, de Wit H.

Psychiatr Genet. 2010 Jun;20(3):85-92. doi: 10.1097/YPG.0b013e32833a1f3c.

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