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TGFbeta protein processing and activity through TCR triggering of primary CD8+ T regulatory cells.

Ménoret A, Myers LM, Lee SJ, Mittler RS, Rossi RJ, Vella AT.

J Immunol. 2006 Nov 1;177(9):6091-7.


CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity.

Mayer CT, Floess S, Baru AM, Lahl K, Huehn J, Sparwasser T.

Eur J Immunol. 2011 Mar;41(3):716-25. doi: 10.1002/eji.201040913. Epub 2011 Feb 11.


Role of IFN-γ in the establishment of anterior chamber-associated immune deviation (ACAID)-induced CD8+ T regulatory cells.

Paunicka K, Chen PW, Niederkorn JY.

J Leukoc Biol. 2012 Mar;91(3):475-83. doi: 10.1189/jlb.0311173. Epub 2011 Dec 16.


Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis.

Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N.

Hepatology. 2012 Dec;56(6):2094-105. doi: 10.1002/hep.25951.


Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression.

O'Sullivan JA, Zloza A, Kohlhapp FJ, Moore TV, Lacek AT, Dulin NO, Guevara-Patiño JA.

Cancer Immunol Immunother. 2011 Nov;60(11):1543-51. doi: 10.1007/s00262-011-1043-1. Epub 2011 Jun 17.


Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta.

Frimpong-Boateng K, van Rooijen N, Geiben-Lynn R.

PLoS One. 2010 Aug 19;5(8):e12281. doi: 10.1371/journal.pone.0012281.


Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.

Scholzen A, Mittag D, Rogerson SJ, Cooke BM, Plebanski M.

PLoS Pathog. 2009 Aug;5(8):e1000543. doi: 10.1371/journal.ppat.1000543. Epub 2009 Aug 14.


Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.

Myers L, Croft M, Kwon BS, Mittler RS, Vella AT.

J Immunol. 2005 Jun 15;174(12):7625-32.


GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo.

Zhou AX, Kozhaya L, Fujii H, Unutmaz D.

J Immunol. 2013 May 15;190(10):5057-64. doi: 10.4049/jimmunol.1300065. Epub 2013 Apr 10.


Profile of regulatory T cells and interferon γ secretion in the tumor-draining lymph node from mouse Hepa1-6 cells.

Wang LK, Kuang M, Hua YP, He Q, Chen B, Wang Y, Peng BG.

J Surg Res. 2013 Aug;183(2):900-6. doi: 10.1016/j.jss.2013.02.001. Epub 2013 Feb 24.


T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.

Fernandez MA, Puttur FK, Wang YM, Howden W, Alexander SI, Jones CA.

J Immunol. 2008 Feb 1;180(3):1556-64.


Plasmodium falciparum soluble extracts potentiate the suppressive function of polyclonal T regulatory cells through activation of TGFβ-mediated signals.

Clemente A, Caporale R, Sannella AR, Majori G, Severini C, Fadigati G, Cirelli D, Bonini P, Garaci E, Cozzolino F, Torcia MG.

Cell Microbiol. 2011 Sep;13(9):1328-38. doi: 10.1111/j.1462-5822.2011.01622.x. Epub 2011 Jun 23.


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