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The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB.

Mol Cell Biol. 2007 Jan;27(1):170-81. Epub 2006 Oct 9.


Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element.

Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M.

Mol Cell Biol. 2006 Mar;26(6):2399-407.


Crucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.

Guess AJ, Ayoob R, Chanley M, Manley J, Cajaiba MM, Agrawal S, Pengal R, Pyle AL, Becknell B, Kopp JB, Ronkina N, Gaestel M, Benndorf R, Smoyer WE.

PLoS One. 2013;8(1):e54239. doi: 10.1371/journal.pone.0054239. Epub 2013 Jan 23.


MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.

Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M.

Biochem Pharmacol. 2010 Dec 15;80(12):1915-20. doi: 10.1016/j.bcp.2010.06.021. Epub 2010 Jun 23. Review.


Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard.

Yego EC, Dillman JF 3rd.

Toxicol In Vitro. 2013 Oct;27(7):2067-75. doi: 10.1016/j.tiv.2013.07.002. Epub 2013 Jul 10.


Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.

Ehlting C, Ronkina N, Böhmer O, Albrecht U, Bode KA, Lang KS, Kotlyarov A, Radzioch D, Gaestel M, Häussinger D, Bode JG.

J Biol Chem. 2011 Jul 8;286(27):24113-24. doi: 10.1074/jbc.M111.235275. Epub 2011 May 17.


Distinct cellular functions of MK2.

Kotlyarov A, Yannoni Y, Fritz S, Laass K, Telliez JB, Pitman D, Lin LL, Gaestel M.

Mol Cell Biol. 2002 Jul;22(13):4827-35.


Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFα production.

Menon MB, Tiedje C, Lafera J, Ronkina N, Konen T, Kotlyarov A, Gaestel M.

Biochem J. 2013 Dec 1;456(2):163-72. doi: 10.1042/BJ20130755. Erratum in: Biochem J. 2014 Jan 1;457(1):229.


MK2 and MK3--a pair of isoenzymes?

Ronkina N, Kotlyarov A, Gaestel M.

Front Biosci. 2008 May 1;13:5511-21. Review.


Mitogen-activated protein kinase p38 and MK2, MK3 and MK5: ménage à trois or ménage à quatre?

Shiryaev A, Moens U.

Cell Signal. 2010 Aug;22(8):1185-92. doi: 10.1016/j.cellsig.2010.03.002. Epub 2010 Mar 11. Review.


Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade.

Ehlting C, Lai WS, Schaper F, Brenndörfer ED, Matthes RJ, Heinrich PC, Ludwig S, Blackshear PJ, Gaestel M, Häussinger D, Bode JG.

J Immunol. 2007 Mar 1;178(5):2813-26.


Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function.

Rigby WF, Roy K, Collins J, Rigby S, Connolly JE, Bloch DB, Brooks SA.

J Immunol. 2005 Jun 15;174(12):7883-93.


MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.

Streicher JM, Ren S, Herschman H, Wang Y.

Circ Res. 2010 Apr 30;106(8):1434-43. doi: 10.1161/CIRCRESAHA.109.213199. Epub 2010 Mar 25.


Post-transcriptional regulation of TNF-induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells: an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27.

Su X, Ao L, Zou N, Song Y, Yang X, Cai GY, Fullerton DA, Meng X.

Biochim Biophys Acta. 2008 Sep;1783(9):1623-31. doi: 10.1016/j.bbamcr.2008.04.009. Epub 2008 Apr 30.


DBM1285 suppresses tumor necrosis factor alpha production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway.

Kang JS, Kim HM, Choi IY, Han SB, Yoon YD, Lee H, Park KH, Cho IJ, Lee CW, Lee K, Lee KH, Park SK.

J Pharmacol Exp Ther. 2010 Aug;334(2):657-64. doi: 10.1124/jpet.109.161687. Epub 2010 Apr 28.


MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.

Culbert AA, Skaper SD, Howlett DR, Evans NA, Facci L, Soden PE, Seymour ZM, Guillot F, Gaestel M, Richardson JC.

J Biol Chem. 2006 Aug 18;281(33):23658-67. Epub 2006 Jun 14.


p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.

Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M.

J Biol Chem. 2010 Oct 22;285(43):33242-51. doi: 10.1074/jbc.M110.132357. Epub 2010 Aug 19.


Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2.

Johansen C, Funding AT, Otkjaer K, Kragballe K, Jensen UB, Madsen M, Binderup L, Skak-Nielsen T, Fjording MS, Iversen L.

J Immunol. 2006 Feb 1;176(3):1431-8.


IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.


Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor.

Bellahcene M, Jacquet S, Cao XB, Tanno M, Haworth RS, Layland J, Kabir AM, Gaestel M, Davis RJ, Flavell RA, Shah AM, Avkiran M, Marber MS.

J Am Coll Cardiol. 2006 Aug 1;48(3):545-55. Epub 2006 Jul 12.

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