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Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D.

Cell. 2006 Oct 6;127(1):99-111.


Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D.

Cell. 2006 Dec 29;127(7):1401-13.


Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

Bashore C, Dambacher CM, Goodall EA, Matyskiela ME, Lander GC, Martin A.

Nat Struct Mol Biol. 2015 Sep;22(9):712-9. doi: 10.1038/nsmb.3075. Epub 2015 Aug 24.


Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.

Mansour W, Nakasone MA, von Delbrück M, Yu Z, Krutauz D, Reis N, Kleifeld O, Sommer T, Fushman D, Glickman MH.

J Biol Chem. 2015 Feb 20;290(8):4688-704. doi: 10.1074/jbc.M114.568295. Epub 2014 Nov 11.


Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome.

Guterman A, Glickman MH.

J Biol Chem. 2004 Jan 16;279(3):1729-38. Epub 2003 Oct 27.


A ubiquitin stress response induces altered proteasome composition.

Hanna J, Meides A, Zhang DP, Finley D.

Cell. 2007 May 18;129(4):747-59.


Deubiquitinating enzymes are IN/(trinsic to proteasome function).

Guterman A, Glickman MH.

Curr Protein Pept Sci. 2004 Jun;5(3):201-11. Review.


Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.

Chernova TA, Allen KD, Wesoloski LM, Shanks JR, Chernoff YO, Wilkinson KD.

J Biol Chem. 2003 Dec 26;278(52):52102-15. Epub 2003 Oct 14. Erratum in: J Biol Chem. 12004 Apr 16;279(16):6894.


Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors.

Chandra A, Chen L, Liang H, Madura K.

J Biol Chem. 2010 Mar 12;285(11):8330-9. doi: 10.1074/jbc.M109.076786. Epub 2010 Jan 8.


Structural characterization of the interaction of Ubp6 with the 26S proteasome.

Aufderheide A, Beck F, Stengel F, Hartwig M, Schweitzer A, Pfeifer G, Goldberg AL, Sakata E, Baumeister W, Förster F.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8626-31. doi: 10.1073/pnas.1510449112. Epub 2015 Jun 30.


Multiple associated proteins regulate proteasome structure and function.

Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT, Walz T, Ploegh H, Finley D.

Mol Cell. 2002 Sep;10(3):495-507.


Extended ubiquitin species are protein-based DUB inhibitors.

Krutauz D, Reis N, Nakasone MA, Siman P, Zhang D, Kirkpatrick DS, Gygi SP, Brik A, Fushman D, Glickman MH.

Nat Chem Biol. 2014 Aug;10(8):664-70. doi: 10.1038/nchembio.1574. Epub 2014 Jul 6.


Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.

Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ.

Science. 2016 Feb 19;351(6275). pii: aad9421. doi: 10.1126/science.aad9421.


Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes.

Lee MJ, Lee BH, Hanna J, King RW, Finley D.

Mol Cell Proteomics. 2011 May;10(5):R110.003871. doi: 10.1074/mcp.R110.003871. Epub 2010 Sep 7. Review.


The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle.

Sakata E, Stengel F, Fukunaga K, Zhou M, Saeki Y, Förster F, Baumeister W, Tanaka K, Robinson CV.

Mol Cell. 2011 Jun 10;42(5):637-49. doi: 10.1016/j.molcel.2011.04.021.


A cryptic protease couples deubiquitination and degradation by the proteasome.

Yao T, Cohen RE.

Nature. 2002 Sep 26;419(6905):403-7. Epub 2002 Sep 1.


The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

Kim HT, Goldberg AL.

J Biol Chem. 2017 Jun 9;292(23):9830-9839. doi: 10.1074/jbc.M116.763128. Epub 2017 Apr 17.


A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.

Joshi KK, Chen L, Torres N, Tournier V, Madura K.

J Mol Biol. 2011 Jul 15;410(3):383-99. doi: 10.1016/j.jmb.2011.05.005. Epub 2011 May 18.


Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.

Peth A, Besche HC, Goldberg AL.

Mol Cell. 2009 Dec 11;36(5):794-804. doi: 10.1016/j.molcel.2009.11.015.


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