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Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress.

Hansson AC, Cippitelli A, Sommer WH, Fedeli A, Björk K, Soverchia L, Terasmaa A, Massi M, Heilig M, Ciccocioppo R.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41. Epub 2006 Oct 2.


Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol.

Hansson AC, Cippitelli A, Sommer WH, Ciccocioppo R, Heilig M.

Addict Biol. 2007 Mar;12(1):30-4.


Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats.

Cippitelli A, Ayanwuyi LO, Barbier E, Domi E, Lerma-Cabrera JM, Carvajal F, Scuppa G, Li H, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R.

Psychopharmacology (Berl). 2015 Mar;232(6):1083-93. doi: 10.1007/s00213-014-3743-7. Epub 2014 Sep 27.


Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.

Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R.

Neuropsychopharmacology. 2012 Mar;37(4):1047-56. doi: 10.1038/npp.2011.297. Epub 2011 Nov 23.


3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

Gehlert DR, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Ciccocioppo R, Heilig M.

J Neurosci. 2007 Mar 7;27(10):2718-26.


Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

Ciccocioppo R, Economidou D, Cippitelli A, Cucculelli M, Ubaldi M, Soverchia L, Lourdusamy A, Massi M.

Addict Biol. 2006 Sep;11(3-4):339-55. Review.


Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats.

Ayanwuyi LO, Carvajal F, Lerma-Cabrera JM, Domi E, Björk K, Ubaldi M, Heilig M, Roberto M, Ciccocioppo R, Cippitelli A.

Front Psychiatry. 2013 Apr 12;4:23. doi: 10.3389/fpsyt.2013.00023. eCollection 2013.


Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.

Sommer WH, Rimondini R, Hansson AC, Hipskind PA, Gehlert DR, Barr CS, Heilig MA.

Biol Psychiatry. 2008 Jan 15;63(2):139-45. Epub 2007 Jun 21.


Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.

Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T.

Alcohol Clin Exp Res. 2014 May;38(5):1275-83. doi: 10.1111/acer.12379. Epub 2014 Mar 10.


[The role of genetic factors on the link between stress and alcohol use: the example of CRH-R1].

Le Strat Y, Dubertret C.

Presse Med. 2012 Jan;41(1):32-6. doi: 10.1016/j.lpm.2011.05.012. Epub 2011 Jul 12. Review. French.


Analysis of the stress response in rats trained in the water-maze: differential expression of corticotropin-releasing hormone, CRH-R1, glucocorticoid receptors and brain-derived neurotrophic factor in limbic regions.

Aguilar-Valles A, Sánchez E, de Gortari P, Balderas I, Ramírez-Amaya V, Bermúdez-Rattoni F, Joseph-Bravo P.

Neuroendocrinology. 2005;82(5-6):306-19. Epub 2006 May 4.


A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.

Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, Jones KA, Müller MB, Uhr M, Holsboer F, Binder EB, Schmidt MV.

Endocrinology. 2014 Jul;155(7):2500-10. doi: 10.1210/en.2013-1986. Epub 2014 Apr 28.


Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling.

Eisenhardt M, Hansson AC, Spanagel R, Bilbao A.

Alcohol Clin Exp Res. 2015 Apr;39(4):752-62. doi: 10.1111/acer.12686.


Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence.

Chen AC, Manz N, Tang Y, Rangaswamy M, Almasy L, Kuperman S, Nurnberger J Jr, O'Connor SJ, Edenberg HJ, Schuckit MA, Tischfield J, Foroud T, Bierut LJ, Rohrbaugh J, Rice JP, Goate A, Hesselbrock V, Porjesz B.

Alcohol Clin Exp Res. 2010 Jun;34(6):988-96. doi: 10.1111/j.1530-0277.2010.01173.x. Epub 2010 Apr 5.


Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kühn R, Reul JM, Holsboer F, Wurst W.

Nat Neurosci. 2003 Oct;6(10):1100-7. Epub 2003 Sep 14.


The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol.

Lê AD, Harding S, Juzytsch W, Fletcher PJ, Shaham Y.

J Neurosci. 2002 Sep 15;22(18):7844-9.


Evidence of lasting dysregulation of neuroendocrine and HPA axis function following global cerebral ischemia in male rats and the effect of Antalarmin on plasma corticosterone level.

de la Tremblaye PB, Raymond J, Milot MR, Merali Z, Plamondon H.

Horm Behav. 2014 Mar;65(3):273-84. doi: 10.1016/j.yhbeh.2014.01.003. Epub 2014 Jan 17.


The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects.

Ray LA, Sehl M, Bujarski S, Hutchison K, Blaine S, Enoch MA.

Genes Brain Behav. 2013 Jun;12(4):361-9. doi: 10.1111/gbb.12032. Epub 2013 Apr 4.


The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats.

Lê AD, Harding S, Juzytsch W, Watchus J, Shalev U, Shaham Y.

Psychopharmacology (Berl). 2000 Jun;150(3):317-24.


Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress.

Bale TL, Contarino A, Smith GW, Chan R, Gold LH, Sawchenko PE, Koob GF, Vale WW, Lee KF.

Nat Genet. 2000 Apr;24(4):410-4.


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