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Items: 1 to 20 of 173


A chemical and genetic approach to the mode of action of fumagillin.

Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM.

Chem Biol. 2006 Sep;13(9):1001-9.


A noncanonical path to mechanism of action.

Peterson RT.

Chem Biol. 2006 Sep;13(9):924-6.


Disruption of Wnt planar cell polarity signaling by aberrant accumulation of the MetAP-2 substrate Rab37.

Sundberg TB, Darricarrere N, Cirone P, Li X, McDonald L, Mei X, Westlake CJ, Slusarski DC, Beynon RJ, Crews CM.

Chem Biol. 2011 Oct 28;18(10):1300-11. doi: 10.1016/j.chembiol.2011.07.020.


Methionine aminopeptidase 2 is required for HSC initiation and proliferation.

Ma AC, Fung TK, Lin RH, Chung MI, Yang D, Ekker SC, Leung AY.

Blood. 2011 Nov 17;118(20):5448-57. doi: 10.1182/blood-2011-04-350173. Epub 2011 Sep 21.


The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2.

Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103.


PAPC and the Wnt5a/Ror2 pathway control the invagination of the otic placode in Xenopus.

Jung B, Köhler A, Schambony A, Wedlich D.

BMC Dev Biol. 2011 Jun 10;11:36. doi: 10.1186/1471-213X-11-36.


Ror2 receptor mediates Wnt11 ligand signaling and affects convergence and extension movements in zebrafish.

Bai Y, Tan X, Zhang H, Liu C, Zhao B, Li Y, Lu L, Liu Y, Zhou J.

J Biol Chem. 2014 Jul 25;289(30):20664-76.


Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled.

Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH.

Exp Mol Med. 2009 Oct 31;41(10):695-706. doi: 10.3858/emm.2009.41.10.076.


Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides.

Kim S, LaMontagne K, Sabio M, Sharma S, Versace RW, Yusuff N, Phillips PE.

Cancer Res. 2004 May 1;64(9):2984-7. Erratum in: Cancer Res. 2004 Dec 15;64(24):9230.


Small molecule inhibitors of methionine aminopeptidase type 2 (MetAP-2).

Garrabrant T, Tuman RW, Ludovici D, Tominovich R, Simoneaux RL, Galemmo RA Jr, Johnson DL.

Angiogenesis. 2004;7(2):91-6.


G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.

Bikkavilli RK, Feigin ME, Malbon CC.

J Cell Sci. 2008 Jan 15;121(Pt 2):234-45. doi: 10.1242/jcs.021964.


Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.

Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO.

Chem Biol. 2009 Feb 27;16(2):193-202. doi: 10.1016/j.chembiol.2009.01.006.


Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.

Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16313-8. Epub 2006 Oct 23.


Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish.

Lou Q, He J, Hu L, Yin Z.

Biochim Biophys Acta. 2012 May;1823(5):1024-32. doi: 10.1016/j.bbamcr.2012.02.013. Epub 2012 Mar 3.


A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.

Kim MS, Yoon SK, Bollig F, Kitagaki J, Hur W, Whye NJ, Wu YP, Rivera MN, Park JY, Kim HS, Malik K, Bell DW, Englert C, Perantoni AO, Lee SB.

J Biol Chem. 2010 May 7;285(19):14585-93. doi: 10.1074/jbc.M109.094334. Epub 2010 Mar 10.


Structure of human methionine aminopeptidase-2 complexed with fumagillin.

Liu S, Widom J, Kemp CW, Crews CM, Clardy J.

Science. 1998 Nov 13;282(5392):1324-7.


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