Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 98


ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.

Trampont P, Zhang L, Ravichandran KS.

Mol Cell Biol. 2006 Dec;26(23):9035-44. Epub 2006 Sep 18.


TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.

Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R.

EMBO J. 2007 Sep 5;26(17):3957-67. Epub 2007 Aug 2.


PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2.

Hu Y, Kang C, Philp RJ, Li B.

Cell Signal. 2007 Feb;19(2):410-8. Epub 2006 Jul 31.


ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

Trampont PC, Zhang L, Giles AJ, Walk SF, Gu JJ, Pendergast AM, Ravichandran KS.

Mol Cell Biol. 2015 Apr;35(8):1462-76. doi: 10.1128/MCB.01084-14. Epub 2015 Feb 17.


Non-redundant role of Shc in Erk activation by cytoskeletal reorganization.

Faisal A, Kleiner S, Nagamine Y.

J Biol Chem. 2004 Jan 30;279(5):3202-11. Epub 2003 Oct 23.


p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.

Arany I, Faisal A, Nagamine Y, Safirstein RL.

J Biol Chem. 2008 Mar 7;283(10):6110-7. doi: 10.1074/jbc.M708799200. Epub 2008 Jan 3.


ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.

Buckley MW, Trampont PC, Arandjelovic S, Fond AM, Juncadella IJ, Ravichandran KS.

J Immunol. 2015 Feb 15;194(4):1665-76. doi: 10.4049/jimmunol.1401728. Epub 2015 Jan 16.


Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly.

McFarland KN, Wilkes SR, Koss SE, Ravichandran KS, Mandell JW.

J Neurosci. 2006 Jul 26;26(30):7885-97.


Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.

Faisal A, el-Shemerly M, Hess D, Nagamine Y.

J Biol Chem. 2002 Aug 16;277(33):30144-52. Epub 2002 Jun 6.


beta1 integrins modulate p66ShcA expression and EGF-induced MAP kinase activation in fetal lung cells.

Smith SM, Crowe DL, Lee MK.

Biochem Biophys Res Commun. 2006 Apr 14;342(3):909-18. Epub 2006 Feb 20.


ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress.

Hu Y, Wang X, Zeng L, Cai DY, Sabapathy K, Goff SP, Firpo EJ, Li B.

Mol Biol Cell. 2005 Aug;16(8):3705-18. Epub 2005 Jun 1.


Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F.

J Biol Chem. 2004 Mar 26;279(13):13224-33. Epub 2003 Dec 9.


Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion.

Northey JJ, Chmielecki J, Ngan E, Russo C, Annis MG, Muller WJ, Siegel PM.

Mol Cell Biol. 2008 May;28(10):3162-76. doi: 10.1128/MCB.01734-07. Epub 2008 Mar 10.


ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.

Ong SH, Dilworth S, Hauck-Schmalenberger I, Pawson T, Kiefer F.

EMBO J. 2001 Nov 15;20(22):6327-36.


c-Jun N-terminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation.

Le S, Connors TJ, Maroney AC.

J Biol Chem. 2001 Dec 21;276(51):48332-6. Epub 2001 Oct 15.


Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules.

Nakamura T, Komiya M, Gotoh N, Koizumi S, Shibuya M, Mori N.

Oncogene. 2002 Jan 3;21(1):22-31.


Supplemental Content

Support Center