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Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.

Eddins MJ, Carlile CM, Gomez KM, Pickart CM, Wolberger C.

Nat Struct Mol Biol. 2006 Oct;13(10):915-20. Epub 2006 Sep 17.


Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.

Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W.

J Cell Biol. 2005 Aug 29;170(5):745-55.


Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes.

McKenna S, Hu J, Moraes T, Xiao W, Ellison MJ, Spyracopoulos L.

Biochemistry. 2003 Jul 8;42(26):7922-30.


Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.

Sato Y, Yamagata A, Goto-Ito S, Kubota K, Miyamoto R, Nakada S, Fukai S.

J Biol Chem. 2012 Jul 27;287(31):25860-8. doi: 10.1074/jbc.M112.364752. Epub 2012 Jun 7.


A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex.

Pastushok L, Moraes TF, Ellison MJ, Xiao W.

J Biol Chem. 2005 May 6;280(18):17891-900. Epub 2005 Mar 4.


Noncovalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated polyubiquitination.

McKenna S, Spyracopoulos L, Moraes T, Pastushok L, Ptak C, Xiao W, Ellison MJ.

J Biol Chem. 2001 Oct 26;276(43):40120-6. Epub 2001 Aug 14.


Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.

VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C.

Cell. 2001 Jun 15;105(6):711-20.


Synthesis of free and proliferating cell nuclear antigen-bound polyubiquitin chains by the RING E3 ubiquitin ligase Rad5.

Carlile CM, Pickart CM, Matunis MJ, Cohen RE.

J Biol Chem. 2009 Oct 23;284(43):29326-34. doi: 10.1074/jbc.M109.043885. Epub 2009 Aug 25.


Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human MMS2.

Lewis MJ, Saltibus LF, Hau DD, Xiao W, Spyracopoulos L.

J Biomol NMR. 2006 Feb;34(2):89-100.


Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling.

Varadan R, Assfalg M, Haririnia A, Raasi S, Pickart C, Fushman D.

J Biol Chem. 2004 Feb 20;279(8):7055-63. Epub 2003 Nov 25.


Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.

Campbell SJ, Edwards RA, Leung CC, Neculai D, Hodge CD, Dhe-Paganon S, Glover JN.

J Biol Chem. 2012 Jul 6;287(28):23900-10. doi: 10.1074/jbc.M112.359653. Epub 2012 May 15.


Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Branigan E, Plechanovov√° A, Jaffray EG, Naismith JH, Hay RT.

Nat Struct Mol Biol. 2015 Aug;22(8):597-602. doi: 10.1038/nsmb.3052. Epub 2015 Jul 6.


Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response.

Wen R, Torres-Acosta JA, Pastushok L, Lai X, Pelzer L, Wang H, Xiao W.

Plant Cell. 2008 Jan;20(1):213-27. doi: 10.1105/tpc.107.051862. Epub 2008 Jan 4.


Mechanistic analysis of PCNA poly-ubiquitylation by the ubiquitin protein ligases Rad18 and Rad5.

Parker JL, Ulrich HD.

EMBO J. 2009 Dec 2;28(23):3657-66. doi: 10.1038/emboj.2009.303. Epub 2009 Oct 22.


The HIP2~ubiquitin conjugate forms a non-compact monomeric thioester during di-ubiquitin synthesis.

Cook BW, Barber KR, Shilton BH, Shaw GS.

PLoS One. 2015 Mar 23;10(3):e0120318. doi: 10.1371/journal.pone.0120318. eCollection 2015.


The mechanism of OTUB1-mediated inhibition of ubiquitination.

Wiener R, Zhang X, Wang T, Wolberger C.

Nature. 2012 Feb 22;483(7391):618-22. doi: 10.1038/nature10911.


E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.

Christensen DE, Brzovic PS, Klevit RE.

Nat Struct Mol Biol. 2007 Oct;14(10):941-8. Epub 2007 Sep 16.


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