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Items: 1 to 20 of 124

1.

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.

Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM.

J Bacteriol. 2006 Nov;188(22):7778-84. Epub 2006 Sep 15.

2.

A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

Székely R, Wáczek F, Szabadkai I, Németh G, Hegymegi-Barakonyi B, Eros D, Szokol B, Pató J, Hafenbradl D, Satchell J, Saint-Joanis B, Cole ST, Orfi L, Klebl BM, Kéri G.

Immunol Lett. 2008 Mar 15;116(2):225-31. doi: 10.1016/j.imlet.2007.12.005. Epub 2008 Jan 8.

PMID:
18258308
3.

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis.

Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM.

Mol Microbiol. 2003 Sep;49(6):1493-508.

4.
5.

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.

Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM.

J Mol Biol. 2005 Jul 29;350(5):953-63.

PMID:
15978616
6.

A protein kinase inhibitor as an antimycobacterial agent.

Drews SJ, Hung F, Av-Gay Y.

FEMS Microbiol Lett. 2001 Dec 18;205(2):369-74.

7.

Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB.

Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena LS, Koduri H, Ghildiyal M, Deol P, Das TK, Tyagi AK, Singh Y.

Biochem Biophys Res Commun. 2003 Nov 7;311(1):112-20.

PMID:
14575702
8.

Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.

Leiba J, Syson K, Baronian G, Zanella-Cléon I, Kalscheuer R, Kremer L, Bornemann S, Molle V.

J Biol Chem. 2013 Jun 7;288(23):16546-56. doi: 10.1074/jbc.M112.398503. Epub 2013 Apr 22.

9.

Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases.

Young TA, Delagoutte B, Endrizzi JA, Falick AM, Alber T.

Nat Struct Biol. 2003 Mar;10(3):168-74.

PMID:
12548283
10.

Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.

Chawla Y, Upadhyay S, Khan S, Nagarajan SN, Forti F, Nandicoori VK.

J Biol Chem. 2014 May 16;289(20):13858-75. doi: 10.1074/jbc.M114.563536. Epub 2014 Apr 4.

11.

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth.

Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV.

Open Biol. 2015 Jul;5(7):150025. doi: 10.1098/rsob.150025.

12.

Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host.

Nagarajan SN, Upadhyay S, Chawla Y, Khan S, Naz S, Subramanian J, Gandotra S, Nandicoori VK.

J Biol Chem. 2015 Apr 10;290(15):9626-45. doi: 10.1074/jbc.M114.611822. Epub 2015 Feb 20.

13.
14.

Role of Mycobacterium tuberculosis Ser/Thr kinase PknF: implications in glucose transport and cell division.

Deol P, Vohra R, Saini AK, Singh A, Chandra H, Chopra P, Das TK, Tyagi AK, Singh Y.

J Bacteriol. 2005 May;187(10):3415-20.

15.

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM.

FEBS Lett. 2006 May 29;580(13):3018-22. Epub 2006 Apr 27.

16.

Accumulation of rifampicin by Mycobacterium aurum, Mycobacterium smegmatis and Mycobacterium tuberculosis.

Piddock LJ, Williams KJ, Ricci V.

J Antimicrob Chemother. 2000 Feb;45(2):159-65.

PMID:
10660497
17.

The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN.

Genes Dev. 2005 Jul 15;19(14):1692-704. Epub 2005 Jun 28.

18.

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.

Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS.

Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11.

19.
20.

The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.

Mir M, Asong J, Li X, Cardot J, Boons GJ, Husson RN.

PLoS Pathog. 2011 Jul;7(7):e1002182. doi: 10.1371/journal.ppat.1002182. Epub 2011 Jul 28.

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