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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.


PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.


Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes.

Kudchodkar SB, Yu Y, Maguire TG, Alwine JC.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14182-7. Epub 2006 Sep 7.


Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.


Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.

Léger B, Cartoni R, Praz M, Lamon S, Dériaz O, Crettenand A, Gobelet C, Rohmer P, Konzelmann M, Luthi F, Russell AP.

J Physiol. 2006 Nov 1;576(Pt 3):923-33. Epub 2006 Aug 17.


Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Sarbassov DD, Guertin DA, Ali SM, Sabatini DM.

Science. 2005 Feb 18;307(5712):1098-101.


RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.


mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.

Zhang Z, Zhang G, Xu X, Su W, Yu B.

Mol Cell Biochem. 2012 Feb;361(1-2):249-57. doi: 10.1007/s11010-011-1110-0. Epub 2011 Nov 5.


The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E.

EMBO J. 2008 Jul 23;27(14):1932-43. doi: 10.1038/emboj.2008.120. Epub 2008 Jun 19.


Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY.

Cancer Res. 2008 Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522.


mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.


Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.

Riaz A, Zeller KS, Johansson S.

PLoS One. 2012;7(2):e32081. doi: 10.1371/journal.pone.0032081. Epub 2012 Feb 22.


Rapamycin regulates the phosphorylation of rictor.

Akcakanat A, Singh G, Hung MC, Meric-Bernstam F.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3. Epub 2007 Aug 8.


Identification of rictor as a novel substrate of Polo-like kinase 1.

Shao T, Liu X.

Cell Cycle. 2015;14(5):755-60. doi: 10.1080/15384101.2014.998050.


Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

Wang JQ, Chen JH, Chen YC, Chen MY, Hsieh CY, Teng SC, Wu KJ.

PLoS One. 2013 Jun 6;8(6):e65586. doi: 10.1371/journal.pone.0065586. Print 2013.


SIN1, a critical component of the mTOR-Rictor complex, is overexpressed and associated with AKT activation in medullary and aggressive papillary thyroid carcinomas.

Moraitis D, Karanikou M, Liakou C, Dimas K, Tzimas G, Tseleni-Balafouta S, Patsouris E, Rassidakis GZ, Kouvaraki MA.

Surgery. 2014 Dec;156(6):1542-8; discussion 1548-9. doi: 10.1016/j.surg.2014.08.095. Epub 2014 Nov 11.


Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

Das F, Ghosh-Choudhury N, Dey N, Mandal CC, Mahimainathan L, Kasinath BS, Abboud HE, Choudhury GG.

J Biol Chem. 2012 Feb 3;287(6):3808-22. doi: 10.1074/jbc.M111.246397. Epub 2011 Dec 19.


mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

García-Martínez JM, Alessi DR.

Biochem J. 2008 Dec 15;416(3):375-85. doi: 10.1042/BJ20081668.


Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.

Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY.

Biochim Biophys Acta. 2013 Oct;1833(10):2135-42. doi: 10.1016/j.bbamcr.2013.05.005. Epub 2013 May 13.

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