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Items: 1 to 20 of 117


Distinct structural elements in the first membrane-spanning segment of the epithelial sodium channel.

Kashlan OB, Maarouf AB, Kussius C, Denshaw RM, Blumenthal KM, Kleyman TR.

J Biol Chem. 2006 Oct 13;281(41):30455-62. Epub 2006 Aug 14.


Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft.

Kashlan OB, Blobner BM, Zuzek Z, Tolino M, Kleyman TR.

J Biol Chem. 2015 Jan 2;290(1):568-76. doi: 10.1074/jbc.M114.606152. Epub 2014 Nov 11.


Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition.

Sheng S, Maarouf AB, Bruns JB, Hughey RP, Kleyman TR.

J Biol Chem. 2007 Jul 13;282(28):20180-90. Epub 2007 May 23.


Ile481 from the guinea pig alpha-subunit plays a major role in the activation of ENaC by cpt-cAMP.

Renauld S, Allache R, Chraibi C.

Cell Physiol Biochem. 2008;22(1-4):101-8. doi: 10.1159/000149787. Epub 2008 Jul 25.


The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.

Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernández J, Dominguez J, Morty RE, Clauss W, González-Hernández T, Alvarez de la Rosa D, Giraldez T.

Am J Physiol Cell Physiol. 2010 Oct;299(4):C779-90. doi: 10.1152/ajpcell.00184.2010. Epub 2010 Jul 14.


ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters.

Hanukoglu I.

FEBS J. 2017 Feb;284(4):525-545. doi: 10.1111/febs.13840. Epub 2016 Sep 15. Review.


Cadmium trapping in an epithelial sodium channel pore mutant.

Takeda AN, Gautschi I, van Bemmelen MX, Schild L.

J Biol Chem. 2007 Nov 2;282(44):31928-36. Epub 2007 Sep 5.


Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response.

Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A, Hanukoglu I.

FEBS J. 2014 Apr;281(8):2097-111. doi: 10.1111/febs.12765. Epub 2014 Mar 17.


Identification of a functional phosphatidylinositol 3,4,5-trisphosphate binding site in the epithelial Na+ channel.

Pochynyuk O, Staruschenko A, Tong Q, Medina J, Stockand JD.

J Biol Chem. 2005 Nov 11;280(45):37565-71. Epub 2005 Sep 9.


A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel.

Gründer S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP, Rossier BC.

EMBO J. 1997 Mar 3;16(5):899-907.


A pore segment in DEG/ENaC Na(+) channels.

Snyder PM, Olson DR, Bucher DB.

J Biol Chem. 1999 Oct 1;274(40):28484-90.


A new subunit of the epithelial Na+ channel identifies regions involved in Na+ self-inhibition.

Babini E, Geisler HS, Siba M, Gründer S.

J Biol Chem. 2003 Aug 1;278(31):28418-26. Epub 2003 May 21.


Role of the C-terminal part of the extracellular domain of the alpha-ENaC in activation by sulfonylurea glibenclamide.

Renauld S, Chraibi A.

J Membr Biol. 2009 Aug;230(3):133-41. doi: 10.1007/s00232-009-9193-1. Epub 2009 Aug 21.


An external site controls closing of the epithelial Na+ channel ENaC.

Kellenberger S, Gautschi I, Schild L.

J Physiol. 2002 Sep 1;543(Pt 2):413-24.


Role of the wrist domain in the response of the epithelial sodium channel to external stimuli.

Shi S, Carattino MD, Kleyman TR.

J Biol Chem. 2012 Dec 28;287(53):44027-35. doi: 10.1074/jbc.M112.421743. Epub 2012 Nov 9.


Structural and functional features of the transmembrane domain of the Na,K-ATPase beta subunit revealed by tryptophan scanning.

Hasler U, Crambert G, Horisberger JD, Geering K.

J Biol Chem. 2001 May 11;276(19):16356-64. Epub 2001 Feb 13.


cAMP sensitivity conferred to the epithelial Na+ channel by alpha-subunit cloned from guinea-pig colon.

Schnizler M, Mastroberardino L, Reifarth F, Weber WM, Verrey F, Clauss W.

Pflugers Arch. 2000 Mar;439(5):579-87.


Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells.

Hanwell D, Ishikawa T, Saleki R, Rotin D.

J Biol Chem. 2002 Mar 22;277(12):9772-9. Epub 2001 Dec 28.


The NH(2) terminus of the epithelial sodium channel contains an endocytic motif.

Chalfant ML, Denton JS, Langloh AL, Karlson KH, Loffing J, Benos DJ, Stanton BA.

J Biol Chem. 1999 Nov 12;274(46):32889-96.


Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach.

Firsov D, Schild L, Gautschi I, Mérillat AM, Schneeberger E, Rossier BC.

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15370-5.

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