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Items: 1 to 20 of 104

1.
2.

The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.

Viola RE, Liu X, Ohren JF, Faehnle CR.

Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):321-30. doi: 10.1107/S0907444907068552.

PMID:
18323627
3.

Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.

Arachea BT, Liu X, Pavlovsky AG, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):205-12. doi: 10.1107/S0907444909052834.

PMID:
20124701
4.

Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.

Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE.

Biochemistry. 2001 Dec 4;40(48):14475-83.

PMID:
11724560
5.

A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii.

Faehnle CR, Ohren JF, Viola RE.

J Mol Biol. 2005 Nov 11;353(5):1055-68.

PMID:
16225889
6.

Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Faehnle CR, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1808-15.

PMID:
15388927
7.

Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis.

Hadfield A, Kryger G, Ouyang J, Petsko GA, Ringe D, Viola R.

J Mol Biol. 1999 Jun 18;289(4):991-1002.

PMID:
10369777
8.

Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Viola RE.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12613-7.

9.

The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1388-95.

PMID:
15272161
10.

Molecular modelling and comparative structural account of aspartyl beta-semialdehyde dehydrogenase of Mycobacterium tuberculosis (H37Rv).

Singh A, Kushwaha HR, Sharma P.

J Mol Model. 2008 Apr;14(4):249-63. doi: 10.1007/s00894-008-0267-2.

PMID:
18236087
11.

A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.

Pavlovsky AG, Thangavelu B, Bhansali P, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3244-52. doi: 10.1107/S1399004714023979.

PMID:
25478842
12.

High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate beta-semialdehyde dehydrogenase.

Nichols CE, Dhaliwal B, Lockyer M, Hawkins AR, Stammers DK.

J Mol Biol. 2004 Aug 13;341(3):797-806.

PMID:
15288787
13.

Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.

Vyas R, Tewari R, Weiss MS, Karthikeyan S.

Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):671-9. doi: 10.1107/S0907444912007330.

PMID:
22683789
14.

Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase.

Faehnle CR, Blanco J, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2320-4.

PMID:
15583380
15.

A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae.

Blanco J, Moore RA, Kabaleeswaran V, Viola RE.

Protein Sci. 2003 Jan;12(1):27-33.

16.

Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species.

Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S.

Sci Rep. 2016 Feb 12;6:21067. doi: 10.1038/srep21067.

17.

Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.

Thangavelu B, Bhansali P, Viola RE.

Bioorg Med Chem. 2015 Oct 15;23(20):6622-31. doi: 10.1016/j.bmc.2015.09.017.

18.

Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.

Dahal G, Viola RE.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1365-71. doi: 10.1107/S2053230X15017495.

19.

Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.

Evitt AS, Cox RJ.

Mol Biosyst. 2011 May;7(5):1564-75. doi: 10.1039/c0mb00227e.

PMID:
21369577
20.

Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).

Cherney LT, Cherney MM, Garen CR, Niu C, Moradian F, James MN.

J Mol Biol. 2007 Apr 13;367(5):1357-69.

PMID:
17316682

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