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Items: 1 to 20 of 82

1.

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.

Nat Immunol. 2006 Sep;7(9):962-70. Epub 2006 Jul 23.

PMID:
16862162
2.

Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.

Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.

J Immunol. 2006 Dec 1;177(11):7520-4.

3.

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

Yang Y, Yin C, Pandey A, Abbott D, Sassetti C, Kelliher MA.

J Biol Chem. 2007 Dec 14;282(50):36223-9. Epub 2007 Oct 18.

4.

The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.

Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.

J Virol. 2007 Dec;81(24):13735-42. Epub 2007 Oct 17.

5.

E2 Polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.

Sayama K, Yamamoto M, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K.

J Biol Chem. 2010 Sep 24;285(39):30042-9. doi: 10.1074/jbc.M110.106484. Epub 2010 Jul 27.

6.

Helicobacter pylori activates NF-κB by inducing Ubc13-mediated ubiquitination of lysine 158 of TAK1.

Lamb A, Chen J, Blanke SR, Chen LF.

J Cell Biochem. 2013 Oct;114(10):2284-92. doi: 10.1002/jcb.24573.

8.

STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.

Zhang H, Hu H, Greeley N, Jin J, Matthews AJ, Ohashi E, Caetano MS, Li HS, Wu X, Mandal PK, McMurray JS, Moghaddam SJ, Sun SC, Watowich SS.

Nat Commun. 2014 Dec 15;5:5798. doi: 10.1038/ncomms6798.

9.

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.

Lamothe B, Besse A, Campos AD, Webster WK, Wu H, Darnay BG.

J Biol Chem. 2007 Feb 9;282(6):4102-12. Epub 2006 Nov 29.

10.

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.

Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M.

Science. 2008 Aug 1;321(5889):663-8. doi: 10.1126/science.1157340. Epub 2008 Jul 17.

11.

Regulation of the nuclear factor (NF)-kappaB pathway by ISGylation.

Minakawa M, Sone T, Takeuchi T, Yokosawa H.

Biol Pharm Bull. 2008 Dec;31(12):2223-7.

12.

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A.

Andersen PL, Zhou H, Pastushok L, Moraes T, McKenna S, Ziola B, Ellison MJ, Dixit VM, Xiao W.

J Cell Biol. 2005 Aug 29;170(5):745-55.

13.

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.

Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM.

Nature. 2004 Jan 8;427(6970):167-71. Epub 2003 Dec 24.

PMID:
14695475
14.

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z.

EMBO J. 2004 Jan 28;23(2):322-32. Epub 2004 Jan 8.

15.

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.

Fukushima T, Matsuzawa S, Kress CL, Bruey JM, Krajewska M, Lefebvre S, Zapata JM, Ronai Z, Reed JC.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6371-6. Epub 2007 Apr 2.

16.

The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway.

Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y, Fan Z.

J Immunol. 2015 Feb 1;194(3):1292-303. doi: 10.4049/jimmunol.1402593. Epub 2014 Dec 29.

17.

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.

Hodge CD, Edwards RA, Markin CJ, McDonald D, Pulvino M, Huen MS, Zhao J, Spyracopoulos L, Hendzel MJ, Glover JN.

ACS Chem Biol. 2015 Jul 17;10(7):1718-28. doi: 10.1021/acschembio.5b00222. Epub 2015 May 1.

18.

Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, Reya T, Karin M.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. Epub 2014 Sep 4.

19.

Control of p53 multimerization by Ubc13 is JNK-regulated.

Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZA.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12676-81. doi: 10.1073/pnas.0900596106. Epub 2009 Jul 27.

20.

Innate immune signaling in Drosophila is regulated by transforming growth factor β (TGFβ)-activated kinase (Tak1)-triggered ubiquitin editing.

Chen L, Paquette N, Mamoor S, Rus F, Nandy A, Leszyk J, Shaffer SA, Silverman N.

J Biol Chem. 2017 May 26;292(21):8738-8749. doi: 10.1074/jbc.M117.788158. Epub 2017 Apr 4.

PMID:
28377500

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