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Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.

Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M.

Blood. 2006 Nov 15;108(10):3603-10. Epub 2006 Jul 20.


Isovolemic exchange transfusion with increasing concentrations of low oxygen affinity hemoglobin solution limits oxygen delivery due to vasoconstriction.

Cabrales P, Tsai AG, Intaglietta M.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2212-8. doi: 10.1152/ajpheart.00751.2008. Epub 2008 Oct 3.


Molecular dimensions of Hb-based O(2) carriers determine constriction of resistance arteries and hypertension.

Sakai H, Hara H, Yuasa M, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M.

Am J Physiol Heart Circ Physiol. 2000 Sep;279(3):H908-15.


Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction.

Cabrales P, Sun G, Zhou Y, Harris DR, Tsai AG, Intaglietta M, Palmer AF.

J Appl Physiol (1985). 2009 Nov;107(5):1548-58. doi: 10.1152/japplphysiol.00622.2009. Epub 2009 Sep 10.


Vasoconstrictive response of rat mesenteric arterioles following infusion of cross-linked, polymerized, and conjugated hemoglobin solutions.

Caron A, Malfatti E, Aguejouf O, Faivre-Fiorina B, Menu P.

Artif Cells Blood Substit Immobil Biotechnol. 2001 Jan;29(1):19-30.


Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis.

Minneci PC, Deans KJ, Shiva S, Zhi H, Banks SM, Kern S, Natanson C, Solomon SB, Gladwin MT.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H743-54. doi: 10.1152/ajpheart.00151.2008. Epub 2008 Jun 13.


Microcirculation and NO-CO studies of a natural extracellular hemoglobin developed for an oxygen therapeutic carrier.

Tsai AG, Intaglietta M, Sakai H, Delpy E, La Rochelle CD, Rousselot M, Zal F.

Curr Drug Discov Technol. 2012 Sep;9(3):166-72.


Balance between vasoconstriction and enhanced oxygen delivery.

Cabrales P, Tsai AG, Intaglietta M.

Transfusion. 2008 Oct;48(10):2087-95. doi: 10.1111/j.1537-2995.2008.01834.x. Epub 2008 Jul 9.


Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure.

Cabrales P, Tsai AG, Winslow RM, Intaglietta M.

Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2146-53. Epub 2005 Jan 6.


Fluid resuscitation with hemoglobin vesicles in a rabbit model of acute hemorrhagic shock.

Terajima K, Tsueshita T, Sakamoto A, Ogawa R.

Shock. 2006 Feb;25(2):184-9.


Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide.

Cabrales P, Han G, Nacharaju P, Friedman AJ, Friedman JM.

Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H49-56. doi: 10.1152/ajpheart.00665.2010. Epub 2010 Nov 5.


Vasoconstrictor effects in isolated rabbit heart perfused with bis(3,5-dibromosalicyl)fumarate cross-linked hemoglobin (alpha alpha Hb).

Macdonald VW, Motterlini R.

Artif Cells Blood Substit Immobil Biotechnol. 1994;22(3):565-75.


Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier.

Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM.

Anesthesiology. 2010 Mar;112(3):586-94. doi: 10.1097/ALN.0b013e3181cd7838.


Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.

Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):200-9. doi: 10.1165/rcmb.2008-0364OC. Epub 2009 Apr 24.


Hemoglobin encapsulation in vesicles retards NO and CO binding and O2 release when perfused through narrow gas-permeable tubes.

Sakai H, Okuda N, Sato A, Yamaue T, Takeoka S, Tsuchida E.

Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H956-65. doi: 10.1152/ajpheart.00741.2009. Epub 2009 Dec 31.


Low oxygen-affinity hemoglobin solution increases oxygenation of partially ischemic tissue during acute anemia.

Cabrales P.

J Am Coll Surg. 2010 Mar;210(3):271-9. doi: 10.1016/j.jamcollsurg.2009.11.005.


Effect of polyethylene glycol conjugated bovine hemoglobin in both top-load and exchange transfusion rat models.

Conover CD, Linberg R, Gilbert CW, Shum KL, Shorr RG.

Artif Organs. 1997 Oct;21(10):1066-75.


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