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Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases.

Vyas PM, Roychowdhury S, Koukouritaki SB, Hines RN, Krueger SK, Williams DE, Nauseef WM, Svensson CK.

J Pharmacol Exp Ther. 2006 Oct;319(1):497-505. Epub 2006 Jul 20.


Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: I. Expression and role of cytochromes P450.

Vyas PM, Roychowdhury S, Khan FD, Prisinzano TE, Lamba J, Schuetz EG, Blaisdell J, Goldstein JA, Munson KL, Hines RN, Svensson CK.

J Pharmacol Exp Ther. 2006 Oct;319(1):488-96. Epub 2006 Jul 20.


Characterization of the formation and localization of sulfamethoxazole and dapsone-associated drug-protein adducts in human epidermal keratinocytes.

Roychowdhury S, Vyas PM, Reilly TP, Gaspari AA, Svensson CK.

J Pharmacol Exp Ther. 2005 Jul;314(1):43-52. Epub 2005 Mar 22.


Formation and uptake of arylhydroxylamine-haptenated proteins in human dendritic cells.

Roychowdhury S, Vyas PM, Svensson CK.

Drug Metab Dispos. 2007 Apr;35(4):676-81. Epub 2007 Jan 12.


Bioactivation, protein haptenation, and toxicity of sulfamethoxazole and dapsone in normal human dermal fibroblasts.

Bhaiya P, Roychowdhury S, Vyas PM, Doll MA, Hein DW, Svensson CK.

Toxicol Appl Pharmacol. 2006 Sep 1;215(2):158-67. Epub 2006 Apr 17.


Role of human cyclooxygenase-2 in the bioactivation of dapsone and sulfamethoxazole.

Vyas PM, Roychowdhury S, Svensson CK.

Drug Metab Dispos. 2006 Jan;34(1):16-8. Epub 2005 Oct 7.


Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes.

Khan FD, Vyas PM, Gaspari AA, Svensson CK.

J Pharmacol Exp Ther. 2007 Dec;323(3):771-7. Epub 2007 Aug 31.


Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase.

Ogese MO, Jenkins RE, Maggs JL, Meng X, Whitaker P, Peckham D, Faulkner L, Park BK, Naisbitt DJ.

Chem Res Toxicol. 2015 Jan 20;28(1):144-54. doi: 10.1021/tx500458k. Epub 2015 Jan 7.


Detection of haptenated proteins in organotypic human skin explant cultures exposed to dapsone.

Roychowdhury S, Cram AE, Aly A, Svensson CK.

Drug Metab Dispos. 2007 Sep;35(9):1463-5. Epub 2007 Jun 6.


Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes.

Clement B, Behrens D, Amschler J, Matschke K, Wolf S, Havemeyer A.

Life Sci. 2005 May 27;77(2):205-19. Epub 2005 Feb 8.


Haptenation of sulfonamide reactive metabolites to cellular proteins.

Manchanda T, Hess D, Dale L, Ferguson SG, Rieder MJ.

Mol Pharmacol. 2002 Nov;62(5):1011-26.


A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions.

Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK.

J Invest Dermatol. 2000 Jun;114(6):1164-73.


Effect of pro-inflammatory cytokines on the toxicity of the arylhydroxylamine metabolites of sulphamethoxazole and dapsone in normal human keratinocytes.

Khan FD, Roychowdhury S, Nemes R, Vyas PM, Woster PM, Svensson CK.

Toxicology. 2006 Feb 1;218(2-3):90-9. Epub 2005 Nov 14.


Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity.

Naisbitt DJ, Hough SJ, Gill HJ, Pirmohamed M, Kitteringham NR, Park BK.

Br J Pharmacol. 1999 Mar;126(6):1393-407.


N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system.

Uetrecht JP, Shear NH, Zahid N.

Drug Metab Dispos. 1993 Sep-Oct;21(5):830-4.


Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.

Uno Y, Shimizu M, Yamazaki H.

Biochem Pharmacol. 2013 Jun 15;85(12):1837-47. doi: 10.1016/j.bcp.2013.04.012. Epub 2013 Apr 23.


Cloning, sequencing, and tissue-dependent expression of flavin-containing monooxygenase (FMO) 1 and FMO3 in the dog.

Lattard V, Longin-Sauvageon C, Lachuer J, Delatour P, Benoit E.

Drug Metab Dispos. 2002 Feb;30(2):119-28.


Sulfonamide-induced reactions in desensitized patients with AIDS--the role of covalent protein haptenation by sulfamethoxazole.

Gruchalla RS, Pesenko RD, Do TT, Skiest DJ.

J Allergy Clin Immunol. 1998 Mar;101(3):371-8.


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