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Items: 1 to 20 of 77

1.

Drug discovery in the ubiquitin-proteasome system.

Nalepa G, Rolfe M, Harper JW.

Nat Rev Drug Discov. 2006 Jul;5(7):596-613. Review.

PMID:
16816840
2.

Emerging role of the ubiquitin-proteasome system as drug targets.

Kar G, Keskin O, Fraternali F, Gursoy A.

Curr Pharm Des. 2013;19(18):3175-89. Review.

PMID:
23151131
3.

Therapeutic strategies within the ubiquitin proteasome system.

Eldridge AG, O'Brien T.

Cell Death Differ. 2010 Jan;17(1):4-13. doi: 10.1038/cdd.2009.82. Review.

4.

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.

Edelmann MJ, Nicholson B, Kessler BM.

Expert Rev Mol Med. 2011 Nov 17;13:e35. doi: 10.1017/S1462399411002031. Review.

5.

Strategies for the identification of ubiquitin ligase inhibitors.

Goldenberg SJ, Marblestone JG, Mattern MR, Nicholson B.

Biochem Soc Trans. 2010 Feb;38(Pt 1):132-6. doi: 10.1042/BST0380132. Review.

6.

The ubiquitin proteasome system as a potential target for the treatment of neurodegenerative diseases.

Ying Z, Wang H, Wang G.

Curr Pharm Des. 2013;19(18):3305-14. Review.

PMID:
23151138
7.

The ubiquitin system, disease, and drug discovery.

Petroski MD.

BMC Biochem. 2008 Oct 21;9 Suppl 1:S7. doi: 10.1186/1471-2091-9-S1-S7. Review.

8.

Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.

Landré V, Rotblat B, Melino S, Bernassola F, Melino G.

Oncotarget. 2014 Sep 30;5(18):7988-8013. Review.

9.

Searching for the boundaries: unlimited expansion of ubiquitin and ubiquitin-like signals in multiple cellular functions.

Crosas B, Farràs R, Marfany G, Rodríguez MS, Thomson TM.

Biochem Soc Trans. 2010 Feb;38(Pt 1):1-5. doi: 10.1042/BST0380001.

PMID:
20074026
10.

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE.

Nat Rev Drug Discov. 2011 Jan;10(1):29-46. doi: 10.1038/nrd3321. Epub 2010 Dec 10. Review.

PMID:
21151032
11.

Development of inhibitors in the ubiquitination cascade.

Zhang W, Sidhu SS.

FEBS Lett. 2014 Jan 21;588(2):356-67. doi: 10.1016/j.febslet.2013.11.003. Epub 2013 Nov 12. Review.

12.

Ubiquitin-protein ligases--novel therapeutic targets?

Robinson PA, Ardley HC.

Curr Protein Pept Sci. 2004 Jun;5(3):163-76. Review.

PMID:
15180521
13.

The role of ubiquitin ligases in cardiac disease.

Willis MS, Bevilacqua A, Pulinilkunnil T, Kienesberger P, Tannu M, Patterson C.

J Mol Cell Cardiol. 2014 Jun;71:43-53. doi: 10.1016/j.yjmcc.2013.11.008. Epub 2013 Nov 19. Review.

14.

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology.

Schwartz AL, Ciechanover A.

Annu Rev Pharmacol Toxicol. 2009;49:73-96. doi: 10.1146/annurev.pharmtox.051208.165340. Review.

PMID:
18834306
15.

The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications.

Ciechanover A, Orian A, Schwartz AL.

J Cell Biochem Suppl. 2000;34:40-51. Review.

PMID:
10762014
16.

Fluorescent reporters for the ubiquitin-proteasome system.

Salomons FA, Verhoef LG, Dantuma NP.

Essays Biochem. 2005;41:113-28. Review.

PMID:
16250901
17.

The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?

Dennissen FJ, Kholod N, van Leeuwen FW.

Prog Neurobiol. 2012 Feb;96(2):190-207. doi: 10.1016/j.pneurobio.2012.01.003. Epub 2012 Jan 16. Review.

PMID:
22270043
18.

Ubiquilin 2: a component of the ubiquitin-proteasome system with an emerging role in neurodegeneration.

Zhang KY, Yang S, Warraich ST, Blair IP.

Int J Biochem Cell Biol. 2014 May;50:123-6. doi: 10.1016/j.biocel.2014.02.018. Epub 2014 Feb 28. Review.

PMID:
24589709
19.

Targeting ubiquitination for cancer therapies.

Morrow JK, Lin HK, Sun SC, Zhang S.

Future Med Chem. 2015;7(17):2333-50. doi: 10.4155/fmc.15.148. Epub 2015 Dec 2. Review.

20.

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection.

Nedelsky NB, Todd PK, Taylor JP.

Biochim Biophys Acta. 2008 Dec;1782(12):691-9. doi: 10.1016/j.bbadis.2008.10.002. Epub 2008 Oct 10. Review.

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