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Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells.

Song X, Chen X, Yamaguchi H, Mouneimne G, Condeelis JS, Eddy RJ.

J Cell Sci. 2006 Jul 15;119(Pt 14):2871-81. Epub 2006 Jun 27.


Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S.

Science. 1999 Aug 6;285(5429):895-8.


Organized migration of epithelial cells requires control of adhesion and protrusion through Rho kinase effectors.

Hopkins AM, Pineda AA, Winfree LM, Brown GT, Laukoetter MG, Nusrat A.

Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G806-17. Epub 2006 Nov 30.


LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics.

Geneste O, Copeland JW, Treisman R.

J Cell Biol. 2002 May 27;157(5):831-8. Epub 2002 May 28.


Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization.

Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K.

Nature. 1998 Jun 25;393(6687):809-12.


Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop.

Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K.

J Biol Chem. 2000 Feb 4;275(5):3577-82.


Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

Heredia L, Helguera P, de Olmos S, Kedikian G, Solá Vigo F, LaFerla F, Staufenbiel M, de Olmos J, Busciglio J, Cáceres A, Lorenzo A.

J Neurosci. 2006 Jun 14;26(24):6533-42.


Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins.

Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY.

Circ Res. 2003 Jun 27;92(12):1296-304. Epub 2003 May 29.


Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex.

Kim YB, Choi S, Choi MC, Oh MA, Lee SA, Cho M, Mizuno K, Kim SH, Lee JW.

J Biol Chem. 2008 Apr 11;283(15):10089-96. doi: 10.1074/jbc.M708300200. Epub 2008 Feb 5.


LIM kinase and slingshot are critical for neurite extension.

Endo M, Ohashi K, Mizuno K.

J Biol Chem. 2007 May 4;282(18):13692-702. Epub 2007 Mar 13.


Cytoplasmic p21Cip1 is involved in Ras-induced inhibition of the ROCK/LIMK/cofilin pathway.

Lee S, Helfman DM.

J Biol Chem. 2004 Jan 16;279(3):1885-91. Epub 2003 Oct 14.


Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension.

Zebda N, Bernard O, Bailly M, Welti S, Lawrence DS, Condeelis JS.

J Cell Biol. 2000 Nov 27;151(5):1119-28.


Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.

San Martín A, Lee MY, Williams HC, Mizuno K, Lassègue B, Griendling KK.

Circ Res. 2008 Feb 29;102(4):432-8. Epub 2007 Dec 20.


Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis.

Mouneimne G, DesMarais V, Sidani M, Scemes E, Wang W, Song X, Eddy R, Condeelis J.

Curr Biol. 2006 Nov 21;16(22):2193-205.


Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis.

Amano T, Kaji N, Ohashi K, Mizuno K.

J Biol Chem. 2002 Jun 14;277(24):22093-102. Epub 2002 Mar 29.


The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.

Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H.

J Biol Chem. 2005 Nov 25;280(47):39524-33. Epub 2005 Sep 16.

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