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Items: 1 to 20 of 123

1.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.

PMID:
16797988
2.

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.

J Med Chem. 2006 Jul 27;49(15):4606-15.

PMID:
16854066
3.

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Onuoha SC, Mukund SR, Coulstock ET, SengerovĂ  B, Shaw J, McLaughlin SH, Jackson SE.

J Mol Biol. 2007 Sep 14;372(2):287-97. Epub 2007 Jun 29.

PMID:
17662999
4.

Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

Jeso V, Iqbal S, Hernandez P, Cameron MD, Park H, LoGrasso PV, Micalizio GC.

Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4800-4. doi: 10.1002/anie.201301323. Epub 2013 Apr 2. No abstract available.

PMID:
23554224
5.

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8.

PMID:
14592488
6.

Development of a fluorescence polarization assay for the molecular chaperone Hsp90.

Kim J, Felts S, Llauger L, He H, Huezo H, Rosen N, Chiosis G.

J Biomol Screen. 2004 Aug;9(5):375-81.

PMID:
15296636
7.

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. Epub 2006 Apr 18.

PMID:
16621545
8.

Improvement of inhibitor identification for heat shock protein 90α by utilizing a red-shifted fluorescence polarization probe.

Qian J, Holskin BP, Theroff J, Underiner T, Meyer SL, Angeles TS.

Assay Drug Dev Technol. 2012 Aug;10(4):375-81. doi: 10.1089/adt.2011.429. Epub 2012 Mar 19.

PMID:
22428803
9.

[3-(Trifluoromethyl)-3H-diazirin-3-yl]coumarin as a carbene-generating photocross-linker with masked fluorogenic beacon.

Tomohiro T, Yamamoto A, Tatsumi Y, Hatanaka Y.

Chem Commun (Camb). 2013 Dec 21;49(98):11551-3. doi: 10.1039/c3cc45780j.

PMID:
24176947
10.

Total synthesis of herbimycin A.

Canova S, Bellosta V, Bigot A, Mailliet P, Mignani S, Cossy J.

Org Lett. 2007 Jan 4;9(1):145-8.

PMID:
17192106
11.

Molecular characterization of macbecin as an Hsp90 inhibitor.

Martin CJ, Gaisser S, Challis IR, Carletti I, Wilkinson B, Gregory M, Prodromou C, Roe SM, Pearl LH, Boyd SM, Zhang MQ.

J Med Chem. 2008 May 8;51(9):2853-7. doi: 10.1021/jm701558c. Epub 2008 Mar 22.

PMID:
18357975
12.

Rational design and synthesis of ansa-adenosines as potential antitumor agents.

Muranaka K, Ichikawa S, Matsuda A.

Nucleic Acids Symp Ser (Oxf). 2009;(53):5-6. doi: 10.1093/nass/nrp003.

PMID:
19749232
13.

Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ.

J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068.

PMID:
18800759
14.

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.

McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.

Org Biomol Chem. 2007 Feb 7;5(3):531-46. Epub 2007 Jan 4.

PMID:
17252137
15.

Inside the Hsp90 inhibitors binding mode through induced fit docking.

Lauria A, Ippolito M, Almerico AM.

J Mol Graph Model. 2009 Feb;27(6):712-22. doi: 10.1016/j.jmgm.2008.11.004. Epub 2008 Nov 8.

PMID:
19084447
16.

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.

Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Otteng M, Ingalls C, Golas JM, Liu H, Lucas J, Boschelli F, Hu Y, Vogan E, Levin JI.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3411-6. doi: 10.1016/j.bmcl.2011.03.112. Epub 2011 Apr 5.

PMID:
21515049
17.

Fluorescence probe with a pH-sensitive trigger.

Galande AK, Weissleder R, Tung CH.

Bioconjug Chem. 2006 Mar-Apr;17(2):255-7.

PMID:
16536452
18.

Structure-based design of 7-carbamate analogs of geldanamycin.

Rastelli G, Tian ZQ, Wang Z, Myles D, Liu Y.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5016-21.

PMID:
16165354
19.

Synthesis and properties of phosphonic acid containing cyanine and squaraine dyes for use as fluorescent labels.

Reddington MV.

Bioconjug Chem. 2007 Nov-Dec;18(6):2178-90. Epub 2007 Oct 11.

PMID:
17927261
20.

Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.

Stravopodis DJ, Margaritis LH, Voutsinas GE.

Curr Med Chem. 2007;14(29):3122-38. Review.

PMID:
18220746

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