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Items: 1 to 20 of 178

1.

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

Xia B, Sheng Q, Nakanishi K, Ohashi A, Wu J, Christ N, Liu X, Jasin M, Couch FJ, Livingston DM.

Mol Cell. 2006 Jun 23;22(6):719-29.

2.

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

Park JY, Singh TR, Nassar N, Zhang F, Freund M, Hanenberg H, Meetei AR, Andreassen PR.

Oncogene. 2014 Oct 2;33(40):4803-12. doi: 10.1038/onc.2013.421. Epub 2013 Oct 21.

3.

PALB2 analysis in BRCA2-like families.

Adank MA, van Mil SE, Gille JJ, Waisfisz Q, Meijers-Heijboer H.

Breast Cancer Res Treat. 2011 Jun;127(2):357-62. doi: 10.1007/s10549-010-1001-1. Epub 2010 Jun 26.

PMID:
20582465
4.

PALB2 is an integral component of the BRCA complex required for homologous recombination repair.

Sy SM, Huen MS, Chen J.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7155-60. doi: 10.1073/pnas.0811159106. Epub 2009 Apr 15.

5.

Therapeutic exploitation of tumor cell defects in homologous recombination.

Powell SN, Kachnic LA.

Anticancer Agents Med Chem. 2008 May;8(4):448-60. Review.

PMID:
18473729
6.

A recurrent mutation in PALB2 in Finnish cancer families.

Erkko H, Xia B, Nikkilä J, Schleutker J, Syrjäkoski K, Mannermaa A, Kallioniemi A, Pylkäs K, Karppinen SM, Rapakko K, Miron A, Sheng Q, Li G, Mattila H, Bell DW, Haber DA, Grip M, Reiman M, Jukkola-Vuorinen A, Mustonen A, Kere J, Aaltonen LA, Kosma VM, Kataja V, Soini Y, Drapkin RI, Livingston DM, Winqvist R.

Nature. 2007 Mar 15;446(7133):316-9. Epub 2007 Feb 7.

PMID:
17287723
7.

Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.

Pylkäs K, Erkko H, Nikkilä J, Sólyom S, Winqvist R.

BMC Cancer. 2008 May 26;8:146. doi: 10.1186/1471-2407-8-146.

8.

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.

Menzel T, Nähse-Kumpf V, Kousholt AN, Klein DK, Lund-Andersen C, Lees M, Johansen JV, Syljuåsen RG, Sørensen CS.

EMBO Rep. 2011 Jul 1;12(7):705-12. doi: 10.1038/embor.2011.99.

9.

PALB2 links BRCA1 and BRCA2 in the DNA-damage response.

Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B, Yu X.

Curr Biol. 2009 Mar 24;19(6):524-9. doi: 10.1016/j.cub.2009.02.018. Epub 2009 Mar 5.

10.

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.

Hellebrand H, Sutter C, Honisch E, Gross E, Wappenschmidt B, Schem C, Deissler H, Ditsch N, Gress V, Kiechle M, Bartram CR, Schmutzler RK, Niederacher D, Arnold N, Meindl A.

Hum Mutat. 2011 Jun;32(6):E2176-88. doi: 10.1002/humu.21478. Epub 2011 Feb 24.

PMID:
21618343
11.

Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer.

Potapova A, Hoffman AM, Godwin AK, Al-Saleem T, Cairns P.

Cancer Res. 2008 Feb 15;68(4):998-1002. doi: 10.1158/0008-5472.CAN-07-2418.

12.

Cancer. Complicated supercomplexes.

Livingston DM.

Science. 2009 May 1;324(5927):602-3. doi: 10.1126/science.1174839. No abstract available.

PMID:
19407191
13.

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.

Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R, Neveling K, Kelly P, Seal S, Freund M, Wurm M, Batish SD, Lach FP, Yetgin S, Neitzel H, Ariffin H, Tischkowitz M, Mathew CG, Auerbach AD, Rahman N.

Nat Genet. 2007 Feb;39(2):162-4. Epub 2006 Dec 31.

PMID:
17200671
14.

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.

Tutt A, Ashworth A.

Trends Mol Med. 2002 Dec;8(12):571-6. Review.

PMID:
12470990
15.

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.

Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8632-7. doi: 10.1073/pnas.1305362110. Epub 2013 May 8.

16.

BRCA2-dependent and independent formation of RAD51 nuclear foci.

Tarsounas M, Davies D, West SC.

Oncogene. 2003 Feb 27;22(8):1115-23.

PMID:
12606939
17.

Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair.

Arnold K, Kim MK, Frerk K, Edler L, Savelyeva L, Schmezer P, Wiedemeyer R.

Cancer Lett. 2006 Nov 8;243(1):90-100. Epub 2006 Jan 31.

PMID:
16448746
18.

Cancer susceptibility and the functions of BRCA1 and BRCA2.

Venkitaraman AR.

Cell. 2002 Jan 25;108(2):171-82. Review.

19.

Analysis of PALB2/FANCN-associated breast cancer families.

Tischkowitz M, Xia B, Sabbaghian N, Reis-Filho JS, Hamel N, Li G, van Beers EH, Li L, Khalil T, Quenneville LA, Omeroglu A, Poll A, Lepage P, Wong N, Nederlof PM, Ashworth A, Tonin PN, Narod SA, Livingston DM, Foulkes WD.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6788-93. Epub 2007 Apr 9.

20.

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