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HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.

Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK.

Immunity. 2006 Jun;24(6):741-52.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.


The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse.

Huang Y, Comiskey EO, Dupree RS, Li S, Koleske AJ, Burkhardt JK.

Blood. 2008 Jul 1;112(1):111-9. doi: 10.1182/blood-2007-10-118232. Epub 2008 Feb 27.


Differently phosphorylated forms of the cortactin homolog HS1 mediate distinct functions in natural killer cells.

Butler B, Kastendieck DH, Cooper JA.

Nat Immunol. 2008 Aug;9(8):887-97. doi: 10.1038/ni.1630. Epub 2008 Jun 29. Erratum in: Nat Immunol. 2008 Oct;9(10):1198.


SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells.

Lettau M, Kabelitz D, Janssen O.

Eur J Immunol. 2015 Feb;45(2):551-61. doi: 10.1002/eji.201444473. Epub 2014 Nov 28.


The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.

Cavnar PJ, Mogen K, Berthier E, Beebe DJ, Huttenlocher A.

J Biol Chem. 2012 Jul 20;287(30):25466-77. doi: 10.1074/jbc.M112.364562. Epub 2012 Jun 7.


Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects.

Paccani SR, Boncristiano M, Patrussi L, Ulivieri C, Wack A, Valensin S, Hirst TR, Amedei A, Del Prete G, Telford JL, D'Elios MM, Baldari CT.

Blood. 2005 Jul 15;106(2):626-34. Epub 2005 Apr 7.


Role of cortactin homolog HS1 in transendothelial migration of natural killer cells.

Mukherjee S, Kim J, Mooren OL, Shahan ST, Cohan M, Cooper JA.

PLoS One. 2015 Feb 27;10(2):e0118153. doi: 10.1371/journal.pone.0118153. eCollection 2015.


Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.

Knyazhitsky M, Moas E, Shaginov E, Luria A, Braiman A.

J Biol Chem. 2012 Jun 1;287(23):19725-35. doi: 10.1074/jbc.M111.309799. Epub 2012 Apr 3.


T cell-specific adapter protein inhibits T cell activation by modulating Lck activity.

Sundvold V, Torgersen KM, Post NH, Marti F, King PD, Røttingen JA, Spurkland A, Lea T.

J Immunol. 2000 Sep 15;165(6):2927-31.


Tyrosine phosphorylation of adaptor protein 3BP2 induces T cell receptor-mediated activation of transcription factor.

Qu X, Kawauchi-Kamata K, Miah SM, Hatani T, Yamamura H, Sada K.

Biochemistry. 2005 Mar 15;44(10):3891-8.


A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation.

Villalba M, Coudronniere N, Deckert M, Teixeiro E, Mas P, Altman A.

Immunity. 2000 Feb;12(2):151-60.


F-actin dynamics control segregation of the TCR signaling cascade to clustered lipid rafts.

Valensin S, Paccani SR, Ulivieri C, Mercati D, Pacini S, Patrussi L, Hirst T, Lupetti P, Baldari CT.

Eur J Immunol. 2002 Feb;32(2):435-46.


Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

Miletic AV, Graham DB, Sakata-Sogawa K, Hiroshima M, Hamann MJ, Cemerski S, Kloeppel T, Billadeau DD, Kanagawa O, Tokunaga M, Swat W.

PLoS One. 2009 Aug 12;4(8):e6599. doi: 10.1371/journal.pone.0006599.


Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.

Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR.

Curr Biol. 1998 May 7;8(10):563-72.


Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

Cao Y, Janssen EM, Duncan AW, Altman A, Billadeau DD, Abraham RT.

EMBO J. 2002 Sep 16;21(18):4809-19.


Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells.

Bartelt RR, Cruz-Orcutt N, Collins M, Houtman JC.

PLoS One. 2009;4(5):e5430. doi: 10.1371/journal.pone.0005430. Epub 2009 May 4.

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