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Items: 1 to 20 of 124

1.
2.

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):117-27. doi: 10.1016/j.jsbmb.2008.05.007. Epub 2008 Jun 21.

PMID:
18620055
3.

Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).

Shahid I, Patel CH, Dhanani S, Owen CP, Ahmed S.

J Steroid Biochem Mol Biol. 2008 May;110(1-2):18-29. doi: 10.1016/j.jsbmb.2007.10.009. Epub 2008 Feb 12.

PMID:
18407491
4.

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).

Ahmed S, Shahid I, Dhanani S, Owen CP.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4698-701. doi: 10.1016/j.bmcl.2009.06.070. Epub 2009 Jun 21.

PMID:
19608417
8.

Synthesis and biological evaluation of imidazole based compounds as cytochrome P-450 inhibitors.

Ahmed S, Smith JH, Nicholls PJ, Whomsley R, Cariuk P.

Drug Des Discov. 1995 Aug;13(1):27-41.

PMID:
8882899
9.
11.

Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17 alpha-hydroxylase: 17, 20-lyase (P450 17) and their specificity patterns.

Bahshwan SA, Owen CP, Nicholls PJ, Smith HJ, Ahmadi M.

J Pharm Pharmacol. 1998 Oct;50(10):1109-16.

PMID:
9821656
12.

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.

Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. doi: 10.1016/j.bmc.2008.07.011. Epub 2008 Jul 9.

PMID:
18674917
13.
14.
15.

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW.

Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. Epub 2007 Nov 4.

PMID:
18061460
16.
17.

Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).

Hartmann RW, Hector M, Wachall BG, Palusczak A, Palzer M, Huch V, Veith M.

J Med Chem. 2000 Nov 16;43(23):4437-45.

PMID:
11087568
18.

17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.

Kaku T, Tsujimoto S, Matsunaga N, Tanaka T, Hara T, Yamaoka M, Kusaka M, Tasaka A.

Bioorg Med Chem. 2011 Apr 1;19(7):2428-42. doi: 10.1016/j.bmc.2011.02.009. Epub 2011 Feb 12.

PMID:
21429754
19.

YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.

Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Fujikura T, Akaza H, Shikama H.

Jpn J Pharmacol. 1999 Feb;79(2):213-20.

20.

Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.

Leroux F.

Curr Med Chem. 2005;12(14):1623-9. Review.

PMID:
16022662

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