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Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.

Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K.

Blood. 2006 Sep 15;108(6):2041-4. Epub 2006 May 23.


Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K.

Blood. 2011 Feb 10;117(6):2022-32. doi: 10.1182/blood-2010-04-280750. Epub 2010 Dec 16.


Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.

Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG.

J Clin Invest. 2004 Feb;113(4):528-38.


An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.

Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J, Tanguturi S, Ladd-Acosta C, Stone R, Golub TR, Raza A.

PLoS Med. 2008 Feb;5(2):e35. doi: 10.1371/journal.pmed.0050035.


Impaired erythropoiesis after haemorrhagic shock in mice is associated with erythroid progenitor apoptosis in vivo.

Robinson Y, Matenov A, Tschöke SK, Weimann A, Oberholzer A, Ertel W, Hostmann A.

Acta Anaesthesiol Scand. 2008 May;52(5):605-13. doi: 10.1111/j.1399-6576.2008.01656.x.


Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.

Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K.

J Clin Invest. 2013 Jan;123(1):335-9. doi: 10.1172/JCI63193. Epub 2012 Dec 10. Erratum in: J Clin Invest. 2016 Jan;126(1):404.


Exogenous iron increases hemoglobin in beta-thalassemic mice.

Ginzburg YZ, Rybicki AC, Suzuka SM, Hall CB, Breuer W, Cabantchik ZI, Bouhassira EE, Fabry ME, Nagel RL.

Exp Hematol. 2009 Feb;37(2):172-83. doi: 10.1016/j.exphem.2008.10.004. Epub 2008 Dec 6.


Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.

Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM.

Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):597-602. Epub 2003 Dec 29.


Oncogenic Kras and Notch-1 cooperate in T-cell acute lymphoblastic leukemia/lymphoma.

Mansour MR.

Expert Rev Hematol. 2009 Apr;2(2):133-6. doi: 10.1586/ehm.09.3.


Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease.

Wahlstrom AM, Cutts BA, Karlsson C, Andersson KM, Liu M, Sjogren AK, Swolin B, Young SG, Bergo MO.

Blood. 2007 Jan 15;109(2):763-8. Epub 2006 Sep 14.


Physiological analysis of oncogenic K-ras.

Pérez-Mancera PA, Tuveson DA.

Methods Enzymol. 2006;407:676-90.


Hereditary anemias of the mouse: a review for geneticists.

Russell ES.

Adv Genet. 1979;20:357-459. Review. No abstract available.


Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Chan G, Kalaitzidis D, Usenko T, Kutok JL, Yang W, Mohi MG, Neel BG.

Blood. 2009 Apr 30;113(18):4414-24. doi: 10.1182/blood-2008-10-182626. Epub 2009 Jan 29.


A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors.

Seidler B, Schmidt A, Mayr U, Nakhai H, Schmid RM, Schneider G, Saur D.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10137-42. doi: 10.1073/pnas.0800487105. Epub 2008 Jul 11.


The myelodysplastic/myeloproliferative disorders: the interface.

Bennett JM.

Hematol Oncol Clin North Am. 2003 Oct;17(5):1095-100, v. Review.


Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis.

Menon MP, Karur V, Bogacheva O, Bogachev O, Cuetara B, Wojchowski DM.

J Clin Invest. 2006 Mar;116(3):683-94.


Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis.

Rey MA, Duffy SP, Brown JK, Kennedy JA, Dick JE, Dror Y, Tailor CS.

Haematologica. 2008 Nov;93(11):1617-26. doi: 10.3324/haematol.13359. Epub 2008 Sep 24.


Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice.

MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G.

Blood. 1999 Mar 15;93(6):2043-56.


Mouse bone marrow and peripheral blood erythroid cell counts are regulated by different autosomal genetic loci.

Jawad M, Giotopoulos G, Fitch S, Cole C, Plumb M, Talbot CJ.

Blood Cells Mol Dis. 2007 Mar-Apr;38(2):69-77. Epub 2006 Dec 20.


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