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Items: 1 to 20 of 125

1.

Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia.

Close P, Hawkes N, Cornez I, Creppe C, Lambert CA, Rogister B, Siebenlist U, Merville MP, Slaugenhaupt SA, Bours V, Svejstrup JQ, Chariot A.

Mol Cell. 2006 May 19;22(4):521-31.

2.

[Molecular and cellular characterization ion of IKAP protein and the Elongator complex. Implications for familial dysautonomia].

Close P, Creppe C, Cornez I, Chariot A.

Bull Mem Acad R Med Belg. 2007;162(5-6):315-22. French. Erratum in: Bull Mem Acad R Med Belg. 2008;163(1-2):159. Close, P [added].

PMID:
18405001
3.

Purification and characterization of the human elongator complex.

Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ.

J Biol Chem. 2002 Jan 25;277(4):3047-52. Epub 2001 Nov 19.

4.

IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia.

Cheishvili D, Maayan C, Cohen-Kupiec R, Lefler S, Weil M, Ast G, Razin A.

Hum Mol Genet. 2011 Apr 15;20(8):1585-94. doi: 10.1093/hmg/ddr036. Epub 2011 Jan 27.

PMID:
21273291
5.

Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia.

Cohen-Kupiec R, Pasmanik-Chor M, Oron-Karni V, Weil M.

PLoS One. 2011 Apr 29;6(4):e19147. doi: 10.1371/journal.pone.0019147.

6.
7.

Loss-of-function of IKAP/ELP1: could neuronal migration defect underlie familial dysautonomia?

Naumanen T, Johansen LD, Coffey ET, Kallunki T.

Cell Adh Migr. 2008 Oct-Dec;2(4):236-9. Epub 2008 Oct 17.

8.

Of splice and men: what does the distribution of IKAP mRNA in the rat tell us about the pathogenesis of familial dysautonomia?

Mezey E, Parmalee A, Szalayova I, Gill SP, Cuajungco MP, Leyne M, Slaugenhaupt SA, Brownstein MJ.

Brain Res. 2003 Sep 5;983(1-2):209-14.

PMID:
12914982
9.

Elongator complex: how many roles does it play?

Svejstrup JQ.

Curr Opin Cell Biol. 2007 Jun;19(3):331-6. Epub 2007 Apr 26. Review.

PMID:
17466506
10.

Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia.

Anderson SL, Qiu J, Rubin BY.

Biochem Biophys Res Commun. 2003 Jun 20;306(1):303-9.

PMID:
12788105
11.

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

Johansen LD, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, Nielsen C, Bøttzauw T, Tolkovsky A, Westermarck J, Coffey ET, Jäättelä M, Kallunki T.

J Cell Sci. 2008 Mar 15;121(Pt 6):854-64. doi: 10.1242/jcs.013722. Epub 2008 Feb 26.

12.

Familial dysautonomia.

Slaugenhaupt SA, Gusella JF.

Curr Opin Genet Dev. 2002 Jun;12(3):307-11. Review.

PMID:
12076674
13.

Plant Elongator regulates auxin-related genes during RNA polymerase II transcription elongation.

Nelissen H, De Groeve S, Fleury D, Neyt P, Bruno L, Bitonti MB, Vandenbussche F, Van der Straeten D, Yamaguchi T, Tsukaya H, Witters E, De Jaeger G, Houben A, Van Lijsebettens M.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1678-83. doi: 10.1073/pnas.0913559107. Epub 2010 Jan 8.

14.

Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia.

Gardiner J, Barton D, Marc J, Overall R.

Traffic. 2007 Sep;8(9):1145-9. Epub 2007 Jul 1.

15.

Human Elongator facilitates RNA polymerase II transcription through chromatin.

Kim JH, Lane WS, Reinberg D.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1241-6. Epub 2002 Jan 29.

16.

IKBKAP mRNA in peripheral blood leukocytes: a molecular marker of gene expression and splicing in familial dysautonomia.

Gold-von Simson G, Leyne M, Mull J, Rolnitzky LM, Goldberg JD, Berlin D, Axelrod FB, Slaugenhaupt SA.

Pediatr Res. 2008 Feb;63(2):186-90.

PMID:
18091349
18.

Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.

Lefler S, Cohen MA, Kantor G, Cheishvili D, Even A, Birger A, Turetsky T, Gil Y, Even-Ram S, Aizenman E, Bashir N, Maayan C, Razin A, Reubinoff BE, Weil M.

PLoS One. 2015 Oct 5;10(10):e0138807. doi: 10.1371/journal.pone.0138807. eCollection 2015.

19.

EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia.

Anderson SL, Qiu J, Rubin BY.

Biochem Biophys Res Commun. 2003 Oct 17;310(2):627-33.

PMID:
14521957
20.

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.

Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2764-9. doi: 10.1073/pnas.1415525112. Epub 2015 Feb 9.

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