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Items: 1 to 20 of 111

1.

Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.

Barber SC, Mead RJ, Shaw PJ.

Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1051-67. Epub 2006 Apr 4. Review.

2.

Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.

Barber SC, Shaw PJ.

Free Radic Biol Med. 2010 Mar 1;48(5):629-41. doi: 10.1016/j.freeradbiomed.2009.11.018. Epub 2009 Dec 4. Review.

PMID:
19969067
4.

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.

Cluskey S, Ramsden DB.

Mol Pathol. 2001 Dec;54(6):386-92. Review.

5.

The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.

Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, Chang Q.

Exp Neurol. 2009 Aug;218(2):333-46. doi: 10.1016/j.expneurol.2009.02.015. Epub 2009 Mar 9.

6.

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.

Qiu L, Qiao T, Beers M, Tan W, Wang H, Yang B, Xu Z.

Mol Neurodegener. 2013 Jan 3;8:1. doi: 10.1186/1750-1326-8-1.

7.
8.

Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration.

Li J, Li T, Zhang X, Tang Y, Yang J, Le W.

Neurobiol Aging. 2014 Apr;35(4):837-46. doi: 10.1016/j.neurobiolaging.2013.09.003. Epub 2013 Oct 11.

PMID:
24126158
9.

Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.

Manfredi G, Xu Z.

Mitochondrion. 2005 Apr;5(2):77-87. Review.

PMID:
16050975
10.

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.

Hossaini M, Cardona Cano S, van Dis V, Haasdijk ED, Hoogenraad CC, Holstege JC, Jaarsma D.

J Neuropathol Exp Neurol. 2011 Aug;70(8):662-77. doi: 10.1097/NEN.0b013e31822581ac.

PMID:
21760539
11.

Iron accumulation promotes TACE-mediated TNF-α secretion and neurodegeneration in a mouse model of ALS.

Lee JK, Shin JH, Gwag BJ, Choi EJ.

Neurobiol Dis. 2015 Aug;80:63-9. doi: 10.1016/j.nbd.2015.05.009. Epub 2015 May 20.

PMID:
26002422
13.

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.

Wong M, Martin LJ.

Hum Mol Genet. 2010 Jun 1;19(11):2284-302. doi: 10.1093/hmg/ddq106. Epub 2010 Mar 10.

15.

Rodent Models of Amyotrophic Lateral Sclerosis.

Philips T, Rothstein JD.

Curr Protoc Pharmacol. 2015 Jun 1;69:5.67.1-21. doi: 10.1002/0471141755.ph0567s69. Review.

16.

Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities.

Magrané J, Hervias I, Henning MS, Damiano M, Kawamata H, Manfredi G.

Hum Mol Genet. 2009 Dec 1;18(23):4552-64. doi: 10.1093/hmg/ddp421. Epub 2009 Sep 24.

17.

Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels.

Zimmerman MC, Oberley LW, Flanagan SW.

J Neurochem. 2007 Aug;102(3):609-18. Epub 2007 Mar 23.

18.

Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.

Ozdinler PH, Benn S, Yamamoto TH, Güzel M, Brown RH Jr, Macklis JD.

J Neurosci. 2011 Mar 16;31(11):4166-77. doi: 10.1523/JNEUROSCI.4184-10.2011.

19.

Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.

Chi L, Ke Y, Luo C, Gozal D, Liu R.

Neuroscience. 2007 Feb 9;144(3):991-1003. Epub 2006 Dec 5.

20.

Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice.

Pehar M, Beeson G, Beeson CC, Johnson JA, Vargas MR.

PLoS One. 2014 Jul 23;9(7):e103438. doi: 10.1371/journal.pone.0103438. eCollection 2014.

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