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Items: 1 to 20 of 68

1.

Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.

Furuno K, Masatsugu T, Sonoda M, Sasazuki T, Yamamoto K.

Biochem Biophys Res Commun. 2006 Jul 7;345(3):1051-8. Epub 2006 May 11.

PMID:
16712789
2.

Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.

Burgos ES, Wilczek C, Onikubo T, Bonanno JB, Jansong J, Reimer U, Shechter D.

J Biol Chem. 2015 Apr 10;290(15):9674-89. doi: 10.1074/jbc.M115.636894. Epub 2015 Feb 24.

3.

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.

Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K.

EMBO J. 2004 Oct 13;23(20):4061-71. Epub 2004 Sep 23.

4.

Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs.

Wilczek C, Chitta R, Woo E, Shabanowitz J, Chait BT, Hunt DF, Shechter D.

J Biol Chem. 2011 Dec 9;286(49):42221-31. doi: 10.1074/jbc.M111.303677. Epub 2011 Oct 18.

5.

The polycomb repressive complex 2 is a potential target of SUMO modifications.

Riising EM, Boggio R, Chiocca S, Helin K, Pasini D.

PLoS One. 2008 Jul 16;3(7):e2704. doi: 10.1371/journal.pone.0002704.

6.

Developmental regulation of Suz 12 localization.

de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y, Panning B.

Chromosoma. 2005 Aug;114(3):183-92. Epub 2005 Jun 29.

PMID:
15986205
7.

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes.

Tae S, Karkhanis V, Velasco K, Yaneva M, Erdjument-Bromage H, Tempst P, Sif S.

Nucleic Acids Res. 2011 Jul;39(13):5424-38. doi: 10.1093/nar/gkr170. Epub 2011 Mar 29.

8.

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.

Chen H, Lorton B, Gupta V, Shechter D.

Oncogene. 2017 Jan 19;36(3):373-386. doi: 10.1038/onc.2016.205. Epub 2016 Jun 6.

9.

Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.

Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ.

Genes Dev. 2004 Jul 1;18(13):1592-605.

10.

A novel WD repeat protein component of the methylosome binds Sm proteins.

Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G.

J Biol Chem. 2002 Mar 8;277(10):8243-7. Epub 2001 Dec 26.

11.

Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.

12.

The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.

Lacroix M, El Messaoudi S, Rodier G, Le Cam A, Sardet C, Fabbrizio E.

EMBO Rep. 2008 May;9(5):452-8. doi: 10.1038/embor.2008.45. Epub 2008 Apr 11.

13.

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.

Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D.

Genes Dev. 2002 Nov 15;16(22):2893-905.

14.

Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.

Ho MC, Wilczek C, Bonanno JB, Xing L, Seznec J, Matsui T, Carter LG, Onikubo T, Kumar PR, Chan MK, Brenowitz M, Cheng RH, Reimer U, Almo SC, Shechter D.

PLoS One. 2013;8(2):e57008. doi: 10.1371/journal.pone.0057008. Epub 2013 Feb 25. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/e6b5348e-9052-4a3b-8f06-90d01dc88fc2.

15.

MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.

Saha K, Adhikary G, Eckert RL.

J Invest Dermatol. 2016 Jan;136(1):214-24. doi: 10.1038/JID.2015.400.

16.

Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3.

Qin S, Guo Y, Xu C, Bian C, Fu M, Gong S, Min J.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):547-53. doi: 10.1016/j.bbrc.2012.11.116. Epub 2012 Dec 7.

PMID:
23228662
17.

Crystal structure of the human PRMT5:MEP50 complex.

Antonysamy S, Bonday Z, Campbell RM, Doyle B, Druzina Z, Gheyi T, Han B, Jungheim LN, Qian Y, Rauch C, Russell M, Sauder JM, Wasserman SR, Weichert K, Willard FS, Zhang A, Emtage S.

Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17960-5. doi: 10.1073/pnas.1209814109. Epub 2012 Oct 15.

18.

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.

Stopa N, Krebs JE, Shechter D.

Cell Mol Life Sci. 2015 Jun;72(11):2041-59. doi: 10.1007/s00018-015-1847-9. Epub 2015 Feb 7. Review.

19.

Structural basis of EZH2 recognition by EED.

Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J.

Structure. 2007 Oct;15(10):1306-15.

20.

Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.

Wang M, Fuhrmann J, Thompson PR.

Biochemistry. 2014 Dec 23;53(50):7884-92. doi: 10.1021/bi501279g. Epub 2014 Dec 8.

PMID:
25485739

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