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Items: 1 to 20 of 76

1.

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

Wehenkel A, Fernandez P, Bellinzoni M, Catherinot V, Barilone N, Labesse G, Jackson M, Alzari PM.

FEBS Lett. 2006 May 29;580(13):3018-22. Epub 2006 Apr 27.

2.

Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases.

Young TA, Delagoutte B, Endrizzi JA, Falick AM, Alber T.

Nat Struct Biol. 2003 Mar;10(3):168-74.

PMID:
12548283
3.

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis.

Ortiz-Lombardía M, Pompeo F, Boitel B, Alzari PM.

J Biol Chem. 2003 Apr 11;278(15):13094-100. Epub 2003 Jan 27.

4.

A novel drug discovery concept for tuberculosis: inhibition of bacterial and host cell signalling.

Székely R, Wáczek F, Szabadkai I, Németh G, Hegymegi-Barakonyi B, Eros D, Szokol B, Pató J, Hafenbradl D, Satchell J, Saint-Joanis B, Cole ST, Orfi L, Klebl BM, Kéri G.

Immunol Lett. 2008 Mar 15;116(2):225-31. doi: 10.1016/j.imlet.2007.12.005. Epub 2008 Jan 8.

PMID:
18258308
5.

PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis.

Boitel B, Ortiz-Lombardía M, Durán R, Pompeo F, Cole ST, Cerveñansky C, Alzari PM.

Mol Microbiol. 2003 Sep;49(6):1493-508.

6.
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8.

The structure of PknB extracellular PASTA domain from mycobacterium tuberculosis suggests a ligand-dependent kinase activation.

Barthe P, Mukamolova GV, Roumestand C, Cohen-Gonsaud M.

Structure. 2010 May 12;18(5):606-15. doi: 10.1016/j.str.2010.02.013.

9.

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.

Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, Cole ST, Alzari PM, Cerveñansky C.

Biochem Biophys Res Commun. 2005 Aug 5;333(3):858-67.

PMID:
15967413
10.

Proteomic identification of M. tuberculosis protein kinase substrates: PknB recruits GarA, a FHA domain-containing protein, through activation loop-mediated interactions.

Villarino A, Duran R, Wehenkel A, Fernandez P, England P, Brodin P, Cole ST, Zimny-Arndt U, Jungblut PR, Cerveñansky C, Alzari PM.

J Mol Biol. 2005 Jul 29;350(5):953-63.

PMID:
15978616
11.

The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth.

Fernandez P, Saint-Joanis B, Barilone N, Jackson M, Gicquel B, Cole ST, Alzari PM.

J Bacteriol. 2006 Nov;188(22):7778-84. Epub 2006 Sep 15.

12.

Phosphoprotein phosphatase of Mycobacterium tuberculosis dephosphorylates serine-threonine kinases PknA and PknB.

Chopra P, Singh B, Singh R, Vohra R, Koul A, Meena LS, Koduri H, Ghildiyal M, Deol P, Das TK, Tyagi AK, Singh Y.

Biochem Biophys Res Commun. 2003 Nov 7;311(1):112-20.

PMID:
14575702
13.

Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosis.

Greenstein AE, Echols N, Lombana TN, King DS, Alber T.

J Biol Chem. 2007 Apr 13;282(15):11427-35. Epub 2007 Jan 22.

14.

Protein kinase B (PknB) of Mycobacterium tuberculosis is essential for growth of the pathogen in vitro as well as for survival within the host.

Chawla Y, Upadhyay S, Khan S, Nagarajan SN, Forti F, Nandicoori VK.

J Biol Chem. 2014 May 16;289(20):13858-75. doi: 10.1074/jbc.M114.563536. Epub 2014 Apr 4.

15.

PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity.

Parikh A, Verma SK, Khan S, Prakash B, Nandicoori VK.

J Mol Biol. 2009 Feb 20;386(2):451-64. doi: 10.1016/j.jmb.2008.12.031. Epub 2008 Dec 24.

PMID:
19121323
16.

Mechanism of autophosphorylation of mycobacterial PknB explored by molecular dynamics simulations.

Damle NP, Mohanty D.

Biochemistry. 2014 Jul 22;53(28):4715-26. doi: 10.1021/bi500245v. Epub 2014 Jul 14.

PMID:
24988180
17.

Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis.

Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6. Epub 2007 Jul 6. Erratum in: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16388.

18.

Allosteric activation mechanism of the Mycobacterium tuberculosis receptor Ser/Thr protein kinase, PknB.

Lombana TN, Echols N, Good MC, Thomsen ND, Ng HL, Greenstein AE, Falick AM, King DS, Alber T.

Structure. 2010 Dec 8;18(12):1667-77. doi: 10.1016/j.str.2010.09.019.

19.

The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth.

Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV.

Open Biol. 2015 Jul;5(7):150025. doi: 10.1098/rsob.150025.

20.

From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division.

Fiuza M, Canova MJ, Zanella-Cléon I, Becchi M, Cozzone AJ, Mateos LM, Kremer L, Gil JA, Molle V.

J Biol Chem. 2008 Jun 27;283(26):18099-112. doi: 10.1074/jbc.M802615200. Epub 2008 Apr 28.

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