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Items: 1 to 20 of 123

1.

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.

Biochem J. 2006 Jul 1;397(1):223-31.

2.

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.

3.
4.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

5.

Structural insights into the recognition of substrates and activators by the OSR1 kinase.

Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.

EMBO Rep. 2007 Sep;8(9):839-45. Epub 2007 Aug 17.

6.

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93. Epub 2005 Oct 31.

7.

A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters.

Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, Delpire E.

J Biol Chem. 2014 Jun 20;289(25):17680-8. doi: 10.1074/jbc.M113.540518. Epub 2014 May 8.

8.

Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.

Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.

J Biol Chem. 2012 Nov 2;287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.

9.

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.

Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.

J Cell Sci. 2008 Mar 1;121(Pt 5):675-84. doi: 10.1242/jcs.025312. Epub 2008 Feb 12.

10.

Cotransporters, WNKs and hypertension: an update.

Flatman PW.

Curr Opin Nephrol Hypertens. 2008 Mar;17(2):186-92. doi: 10.1097/MNH.0b013e3282f5244e. Review.

PMID:
18277153
11.

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT.

Sci Signal. 2014 Jul 15;7(334):re3. doi: 10.1126/scisignal.2005365. Review.

PMID:
25028718
12.

With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.

Mercado A, de Los Heros P, Melo Z, Chávez-Canales M, Murillo-de-Ozores AR, Moreno E, Bazúa-Valenti S, Vázquez N, Hadchouel J, Gamba G.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C54-66. doi: 10.1152/ajpcell.00193.2015. Epub 2016 May 11.

13.
14.

WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells.

Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10883-8. Epub 2006 Jul 10.

15.

Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.

Gagnon KB, England R, Delpire E.

Mol Cell Biol. 2006 Jan;26(2):689-98.

16.

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J.

Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478.

17.

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.

PMID:
22294159
18.

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl- cotransport activity.

Gagnon KB, Delpire E.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C614-20. doi: 10.1152/ajpcell.00074.2010. Epub 2010 May 12.

19.

Critical role of the SPAK protein kinase CCT domain in controlling blood pressure.

Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR.

Hum Mol Genet. 2015 Aug 15;24(16):4545-58. doi: 10.1093/hmg/ddv185. Epub 2015 May 20.

20.

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.

Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D.

Mol Cancer. 2014 Feb 20;13:31. doi: 10.1186/1476-4598-13-31.

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