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Items: 1 to 20 of 146

1.

GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover.

Frank SR, Adelstein MR, Hansen SH.

EMBO J. 2006 May 3;25(9):1848-59. Epub 2006 Apr 20.

2.

Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts.

Lamorte L, Rodrigues S, Sangwan V, Turner CE, Park M.

Mol Biol Cell. 2003 Jul;14(7):2818-31. Epub 2003 Apr 4.

3.

The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.

Frank SR, Köllmann CP, van Lidth de Jeude JF, Thiagarajah JR, Engelholm LH, Frödin M, Hansen SH.

Oncogene. 2017 Mar 30;36(13):1816-1828. doi: 10.1038/onc.2016.345. Epub 2016 Sep 26.

6.

Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.

Zhou W, Li X, Premont RT.

J Cell Sci. 2016 May 15;129(10):1963-74. doi: 10.1242/jcs.179465. Review.

7.

The multifunctional GIT family of proteins.

Hoefen RJ, Berk BC.

J Cell Sci. 2006 Apr 15;119(Pt 8):1469-75. Review.

8.

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Aslan JE, Baker SM, Loren CP, Haley KM, Itakura A, Pang J, Greenberg DL, David LL, Manser E, Chernoff J, McCarty OJ.

Am J Physiol Cell Physiol. 2013 Sep;305(5):C519-28. doi: 10.1152/ajpcell.00418.2012. Epub 2013 Jun 19.

9.

S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin.

Shikata Y, Birukov KG, Garcia JG.

J Appl Physiol (1985). 2003 Mar;94(3):1193-203. Epub 2002 Dec 13.

PMID:
12482769
10.

Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.

Antoku S, Mayer BJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4228-38. doi: 10.1242/jcs.054627. Epub 2009 Oct 27.

11.

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.

Schmalzigaug R, Garron ML, Roseman JT, Xing Y, Davidson CE, Arold ST, Premont RT.

Cell Signal. 2007 Aug;19(8):1733-44. Epub 2007 Mar 30.

12.

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

Zhao ZS, Manser E, Loo TH, Lim L.

Mol Cell Biol. 2000 Sep;20(17):6354-63.

13.

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.

Loo TH, Ng YW, Lim L, Manser E.

Mol Cell Biol. 2004 May;24(9):3849-59.

14.

Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.

Valdes JL, Tang J, McDermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP.

J Biol Chem. 2011 Nov 11;286(45):39403-16. doi: 10.1074/jbc.M111.260802. Epub 2011 Sep 18.

15.
16.

The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors.

Premont RT, Perry SJ, Schmalzigaug R, Roseman JT, Xing Y, Claing A.

Cell Signal. 2004 Sep;16(9):1001-11.

PMID:
15212761
17.

Characterization of the endogenous GIT1-betaPIX complex, and identification of its association to membranes.

Botrugno OA, Paris S, Za L, Gualdoni S, Cattaneo A, Bachi A, de Curtis I.

Eur J Cell Biol. 2006 Jan;85(1):35-46. Epub 2005 Nov 8.

PMID:
16373173
18.

G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.

Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):419-26. doi: 10.1161/ATVBAHA.113.302689. Epub 2013 Nov 21.

19.

Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.

Schmidt MH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I.

Oncogene. 2006 May 18;25(21):3071-8.

PMID:
16407834
20.

GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.

van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC.

Circ Res. 2004 Apr 30;94(8):1041-9. Epub 2004 Mar 11.

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