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Items: 1 to 20 of 94

1.

C-termini of P/Q-type Ca2+ channel alpha1A subunits translocate to nuclei and promote polyglutamine-mediated toxicity.

Kordasiewicz HB, Thompson RM, Clark HB, Gomez CM.

Hum Mol Genet. 2006 May 15;15(10):1587-99. Epub 2006 Apr 4.

PMID:
16595610
2.

Proteolytic cleavage and cellular toxicity of the human alpha1A calcium channel in spinocerebellar ataxia type 6.

Kubodera T, Yokota T, Ohwada K, Ishikawa K, Miura H, Matsuoka T, Mizusawa H.

Neurosci Lett. 2003 Apr 24;341(1):74-8.

PMID:
12676347
3.

The polyglutamine expansion in spinocerebellar ataxia type 6 causes a beta subunit-specific enhanced activation of P/Q-type calcium channels in Xenopus oocytes.

Restituito S, Thompson RM, Eliet J, Raike RS, Riedl M, Charnet P, Gomez CM.

J Neurosci. 2000 Sep 1;20(17):6394-403.

4.

Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death.

Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, Mogushi K, Mahmut Y, Tanaka H, Tsuruta F, Dolmetsch R, Yamada M, Takahashi H, Kato T, Mori O, Eishi Y, Mizusawa H, Ishikawa K.

PLoS One. 2013;8(3):e50121. doi: 10.1371/journal.pone.0050121. Epub 2013 Mar 7.

5.

Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function.

Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T.

J Biol Chem. 2000 Apr 14;275(15):10893-8.

6.

The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells.

Ishiguro T, Ishikawa K, Takahashi M, Obayashi M, Amino T, Sato N, Sakamoto M, Fujigasaki H, Tsuruta F, Dolmetsch R, Arai T, Sasaki H, Nagashima K, Kato T, Yamada M, Takahashi H, Hashizume Y, Mizusawa H.

Acta Neuropathol. 2010 Apr;119(4):447-64. doi: 10.1007/s00401-009-0630-0. Epub 2009 Dec 31.

7.

Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells.

Saegusa H, Wakamori M, Matsuda Y, Wang J, Mori Y, Zong S, Tanabe T.

Mol Cell Neurosci. 2007 Feb;34(2):261-70. Epub 2006 Dec 22.

PMID:
17188510
8.

Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6.

Piedras-Renteria ES, Watase K, Harata N, Zhuchenko O, Zoghbi HY, Lee CC, Tsien RW.

J Neurosci. 2001 Dec 1;21(23):9185-93.

9.

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

Burgess DL, Biddlecome GH, McDonough SI, Diaz ME, Zilinski CA, Bean BP, Campbell KP, Noebels JL.

Mol Cell Neurosci. 1999 Apr;13(4):293-311.

PMID:
10328888
10.

Abundant expression and cytoplasmic aggregations of [alpha]1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6.

Ishikawa K, Fujigasaki H, Saegusa H, Ohwada K, Fujita T, Iwamoto H, Komatsuzaki Y, Toru S, Toriyama H, Watanabe M, Ohkoshi N, Shoji S, Kanazawa I, Tanabe T, Mizusawa H.

Hum Mol Genet. 1999 Jul;8(7):1185-93.

PMID:
10369863
11.

Expression of calcium channel alpha1A mRNA and protein in the leaner mouse (tgla/tgla) cerebellum.

Lau FC, Abbott LC, Rhyu IJ, Kim DS, Chin H.

Brain Res Mol Brain Res. 1998 Aug 15;59(1):93-9.

PMID:
9729301
12.

Differential expression of T-type calcium channels in P/Q-type calcium channel mutant mice with ataxia and absence epilepsy.

Nahm SS, Jung KY, Enger MK, Griffith WH, Abbott LC.

J Neurobiol. 2005 Feb 15;62(3):352-60.

13.

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells.

Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, Rees M.

J Neurosci. 2001 Aug 15;21(16):6095-104.

14.
15.

Functional analysis of a type 1 parathyroid hormone receptor intracellular tail mutant [KRK(484-6)AAA]: effects on second messenger generation and cellular targeting.

Patterson EK, Hodsman AB, Hendy GN, Canaff L, Bringhurst FR, Fraher LJ.

Bone. 2010 Apr;46(4):1180-7. doi: 10.1016/j.bone.2009.12.005. Epub 2009 Dec 16.

PMID:
20006743
16.

Cytoplasmic and nuclear polyglutamine aggregates in SCA6 Purkinje cells.

Ishikawa K, Owada K, Ishida K, Fujigasaki H, Shun Li M, Tsunemi T, Ohkoshi N, Toru S, Mizutani T, Hayashi M, Arai N, Hasegawa K, Kawanami T, Kato T, Makifuchi T, Shoji S, Tanabe T, Mizusawa H.

Neurology. 2001 Jun 26;56(12):1753-6.

PMID:
11425948
17.

Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner.

Lorenzon NM, Lutz CM, Frankel WN, Beam KG.

J Neurosci. 1998 Jun 15;18(12):4482-9.

19.

Polyglutamine repeats of spinocerebellar ataxia 6 impair the cell-death-preventing effect of CaV2.1 Ca2+ channel--loss-of-function cellular model of SCA6.

Matsuyama Z, Yanagisawa NK, Aoki Y, Black JL 3rd, Lennon VA, Mori Y, Imoto K, Inuzuka T.

Neurobiol Dis. 2004 Nov;17(2):198-204.

PMID:
15474358
20.

Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.

Marquèze-Pouey B, Martin-Moutot N, Sakkou-Norton M, Lévêque C, Ji Y, Cornet V, Hsiao WL, Seagar M.

Traffic. 2008 Jul;9(7):1088-100. doi: 10.1111/j.1600-0854.2008.00743.x. Epub 2008 Apr 1.

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