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Items: 1 to 20 of 207

1.

Cytochrome P450s and other enzymes in drug metabolism and toxicity.

Guengerich FP.

AAPS J. 2006 Mar 10;8(1):E101-11. Review.

2.

Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress.

Bhattacharyya S, Sinha K, Sil PC.

Curr Drug Metab. 2014;15(7):719-42. Review.

PMID:
25429675
3.

Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes.

Yamazaki H.

Chem Res Toxicol. 2017 Jan 17;30(1):53-60. doi: 10.1021/acs.chemrestox.6b00286. Epub 2016 Oct 26.

PMID:
27750412
4.

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D.

Drug Metab Rev. 2016 Nov;48(4):473-501. Epub 2016 Sep 20. Review.

PMID:
27533622
5.

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.

Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.

Chem Res Toxicol. 2011 Sep 19;24(9):1345-410. doi: 10.1021/tx200168d. Epub 2011 Jul 11. Review.

PMID:
21702456
6.

Pharmacogenetics in geriatric medicine: challenges and opportunities for clinical practice.

Pilotto A, Panza F, Seripa D.

Curr Drug Metab. 2011 Sep;12(7):621-34. Review.

PMID:
21495974
7.

Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.

Guengerich FP.

Chem Res Toxicol. 2017 Jan 17;30(1):2-12. doi: 10.1021/acs.chemrestox.6b00226. Epub 2016 Aug 11.

8.

Idiosyncratic toxicity: the role of toxicophores and bioactivation.

Williams DP, Park BK.

Drug Discov Today. 2003 Nov 15;8(22):1044-50. Review.

PMID:
14690635
9.

Elucidating mechanisms of drug-induced toxicity.

Liebler DC, Guengerich FP.

Nat Rev Drug Discov. 2005 May;4(5):410-20. Review.

PMID:
15864270
10.

Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.

Powley MW, Frederick CB, Sistare FD, DeGeorge JJ.

Chem Res Toxicol. 2009 Feb;22(2):257-62. doi: 10.1021/tx8004373.

PMID:
19170595
11.

Chemical toxicology: reactive intermediates and their role in pharmacology and toxicology.

Erve JC.

Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):923-46. Review.

PMID:
17125409
12.

Detecting reactive drug metabolites for reducing the potential for drug toxicity.

Grillo MP.

Expert Opin Drug Metab Toxicol. 2015;11(8):1281-302. doi: 10.1517/17425255.2015.1048222. Epub 2015 May 25. Review.

PMID:
26005795
13.

Mechanisms of drug toxicity and relevance to pharmaceutical development.

Guengerich FP.

Drug Metab Pharmacokinet. 2011;26(1):3-14. Epub 2010 Oct 22. Review.

14.

Enzymatic activation of chemicals to toxic metabolites.

Guengerich FP, Liebler DC.

Crit Rev Toxicol. 1985;14(3):259-307. Review.

PMID:
3926381
15.

P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity.

Hart SN, Zhong XB.

Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):439-52. doi: 10.1517/17425255.4.4.439 . Review.

PMID:
18433346
16.

Bioactivation of drugs: risk and drug design.

Walsh JS, Miwa GT.

Annu Rev Pharmacol Toxicol. 2011;51:145-67. doi: 10.1146/annurev-pharmtox-010510-100514. Review.

PMID:
21210745
17.

Cytochrome p450 and chemical toxicology.

Guengerich FP.

Chem Res Toxicol. 2008 Jan;21(1):70-83. Epub 2007 Dec 6. Review.

PMID:
18052394
18.

QM/MM modelling of drug-metabolizing enzymes.

Lonsdale R, Mulholland AJ.

Curr Top Med Chem. 2014;14(11):1339-47. Review.

PMID:
24805066
19.

Streptomyces cytochromes P450: applications in drug metabolism.

Lamb DC, Waterman MR, Zhao B.

Expert Opin Drug Metab Toxicol. 2013 Oct;9(10):1279-94. doi: 10.1517/17425255.2013.806485. Epub 2013 Jun 6. Review.

PMID:
23738914
20.

From the Viewpoint of Drug Metabolism Research.

Nakajima M.

Yakugaku Zasshi. 2017;137(6):697-705. doi: 10.1248/yakushi.16-00250-5. Review. Japanese.

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