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Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.

Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH Jr, Trotti D.

J Biol Chem. 2006 May 19;281(20):14076-84.


Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization.

Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D.

Glia. 2014 Aug;62(8):1241-53. doi: 10.1002/glia.22677.


Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice.

Guo H, Lai L, Butchbach ME, Stockinger MP, Shan X, Bishop GA, Lin CL.

Hum Mol Genet. 2003 Oct 1;12(19):2519-32.


Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D.

Glia. 2011 Nov;59(11):1719-31. doi: 10.1002/glia.21218.


Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).

Vanoni C, Massari S, Losa M, Carrega P, Perego C, Conforti L, Pietrini G.

J Cell Sci. 2004 Oct 15;117(Pt 22):5417-26.


Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Milanese M, Giribaldi F, Melone M, Bonifacino T, Musante I, Carminati E, Rossi PI, Vergani L, Voci A, Conti F, Puliti A, Bonanno G.

Neurobiol Dis. 2014 Apr;64:48-59. doi: 10.1016/j.nbd.2013.11.006.


Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland DW, Rothstein JD.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1604-9.


Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis.

Lin CL, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L, Rothstein JD.

Neuron. 1998 Mar;20(3):589-602.


Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1.

Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD.

Glia. 2010 Feb;58(3):277-86. doi: 10.1002/glia.20922.


Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis.

Foran E, Rosenblum L, Bogush AI, Trotti D.

Neuromolecular Med. 2013 Dec;15(4):760-70. doi: 10.1007/s12017-013-8262-x. Review.


GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1.

Deitch JS, Alexander GM, Del Valle L, Heiman-Patterson TD.

J Neurol Sci. 2002 Jan 15;193(2):117-26.


Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis.

Sala G, Beretta S, Ceresa C, Mattavelli L, Zoia C, Tremolizzo L, Ferri A, Carrì MT, Ferrarese C.

Neurochem Int. 2005 Feb;46(3):227-34.


Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS.

Guégan C, Vila M, Teismann P, Chen C, Onténiente B, Li M, Friedlander RM, Przedborski S.

Mol Cell Neurosci. 2002 Aug;20(4):553-62. Erratum in: Mol Cell Neurosci.2003 Jun;23(2):following table of contents. Teissman P [corrected to Teismann P].


Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.

Milanese M, Bonifacino T, Fedele E, Rebosio C, Cattaneo L, Benfenati F, Usai C, Bonanno G.

Neurobiol Dis. 2015 Feb;74:314-24. doi: 10.1016/j.nbd.2014.12.004.


Impairment of nuclear factor-kappaB activation increased glutamate excitotoxicity in a motoneuron-neuroblastoma hybrid cell line expressing mutant (G93A) Cu/Zn-superoxide dismutase.

Pyo JS, Ko YS, Kim WH, Kim M, Lee KW, Nam SY, Chung HY, Cho SJ, Baik TK, Lee BL.

J Neurosci Res. 2010 Aug 15;88(11):2494-503. doi: 10.1002/jnr.22397.


Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1.

Warita H, Manabe Y, Murakami T, Shiote M, Shiro Y, Hayashi T, Nagano I, Shoji M, Abe K.

Neurol Res. 2002 Sep;24(6):577-81.


GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease.

Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC.

Neurobiol Dis. 2015 Jun;78:12-23. doi: 10.1016/j.nbd.2015.03.010.

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