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Items: 1 to 20 of 175

1.

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.

Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z, Evans RL, Andreeff M.

Blood. 2006 Jul 15;108(2):630-7.

2.

Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.

Kim MJ, Lee TH, Kim SH, Choi YJ, Heo J, Kim YH.

Int J Oncol. 2010 Nov;37(5):1177-85.

PMID:
20878065
3.

Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1.

Nakazato T, Sagawa M, Kizaki M.

Int J Oncol. 2014 Apr;44(4):1131-8. doi: 10.3892/ijo.2014.2280.

PMID:
24481531
4.
5.

Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells.

Hung FM, Chen YL, Huang AC, Hsiao YP, Yang JS, Chung MT, Chueh FS, Lu HF, Chung JG.

Oncol Rep. 2013 Mar;29(3):1053-60. doi: 10.3892/or.2013.2230.

PMID:
23314229
6.

Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.

Wan CK, Wang C, Cheung HY, Yang M, Fong WF.

Cancer Lett. 2006 Sep 8;241(1):31-41.

PMID:
16316721
7.

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML.

Carter BZ, Mak DH, Shi Y, Fidler JM, Chen R, Ling X, Plunkett W, Andreeff M.

Leukemia. 2012 Mar;26(3):443-50. doi: 10.1038/leu.2011.246.

8.

Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway.

Wu PP, Liu KC, Huang WW, Ma CY, Lin H, Yang JS, Chung JG.

Oncol Rep. 2011 Feb;25(2):551-7. doi: 10.3892/or.2010.1080.

PMID:
21152873
9.

The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages.

Bao X, Cui J, Wu Y, Han X, Gao C, Hua Z, Shen P.

J Mol Med (Berl). 2007 Jan;85(1):85-98.

PMID:
17109129
10.

Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.

Yao J, Jiang Z, Duan W, Huang J, Zhang L, Hu L, He L, Li F, Xiao Y, Shu B, Liu C.

Biol Pharm Bull. 2008 Apr;31(4):592-7.

11.

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, Reed JC, Andreeff M.

Blood. 2008 Apr 1;111(7):3742-50. doi: 10.1182/blood-2007-05-091504.

12.

Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.

Liu L, Li G, Li Q, Jin Z, Zhang L, Zhou J, Hu X, Zhou T, Chen J, Gao N.

Cell Death Dis. 2013 Dec 5;4:e941. doi: 10.1038/cddis.2013.469.

13.

Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells.

Choi YJ, Kim TG, Kim YH, Lee SH, Kwon YK, Suh SI, Park JW, Kwon TK.

Biochem Pharmacol. 2003 Jul 15;66(2):273-80.

PMID:
12826269
14.

Triptolide induced cell death through apoptosis and autophagy in murine leukemia WEHI-3 cells in vitro and promoting immune responses in WEHI-3 generated leukemia mice in vivo.

Chan SF, Chen YY, Lin JJ, Liao CL, Ko YC, Tang NY, Kuo CL, Liu KC, Chung JG.

Environ Toxicol. 2017 Feb;32(2):550-568. doi: 10.1002/tox.22259.

PMID:
26990902
15.

Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway.

Wang XF, Zhao YB, Wu Q, Sun ZH, Li HJ.

Mol Med Rep. 2014 Jan;9(1):39-44. doi: 10.3892/mmr.2013.1783.

PMID:
24213358
16.

Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.

Lu N, Liu J, Liu J, Zhang C, Jiang F, Wu H, Chen L, Zeng W, Cao X, Yan T, Wang G, Zhou H, Lin B, Yan X, Zhang XK, Zeng JZ.

PLoS One. 2012;7(4):e35722. doi: 10.1371/journal.pone.0035722.

17.

Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas.

Wu J, Li QQ, Zhou H, Lu Y, Li JM, Ma Y, Wang L, Fu T, Gong X, Weintraub M, Wu S, Ding H.

Med Oncol. 2014 Jul;31(7):14. doi: 10.1007/s12032-014-0014-8.

PMID:
24880464
18.

Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways.

Mujumdar N, Mackenzie TN, Dudeja V, Chugh R, Antonoff MB, Borja-Cacho D, Sangwan V, Dawra R, Vickers SM, Saluja AK.

Gastroenterology. 2010 Aug;139(2):598-608. doi: 10.1053/j.gastro.2010.04.046.

19.

Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.

Panichakul T, Intachote P, Wongkajorsilp A, Sripa B, Sirisinha S.

Anticancer Res. 2006 Jan-Feb;26(1A):259-65.

20.

Triptolide induces apoptosis through extrinsic and intrinsic pathways in human osteosarcoma U2OS cells.

Kwon HY, Kim KS, An HK, Moon HI, Kim HJ, Lee YC.

Indian J Biochem Biophys. 2013 Dec;50(6):485-91.

PMID:
24772972

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