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Items: 1 to 20 of 215

1.

hERG potassium channels and cardiac arrhythmia.

Sanguinetti MC, Tristani-Firouzi M.

Nature. 2006 Mar 23;440(7083):463-9. Review.

PMID:
16554806
2.
3.

[HERG K+ channel, the target of anti-arrhythmias drugs].

Guan FY, Yang SJ.

Yao Xue Xue Bao. 2007 Jul;42(7):687-91. Review. Chinese.

PMID:
17882949
4.

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.

Perrin MJ, Subbiah RN, Vandenberg JI, Hill AP.

Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):137-48. doi: 10.1016/j.pbiomolbio.2008.10.006. Epub 2008 Nov 5. Review.

PMID:
19027781
5.

hERG potassium channels and the structural basis of drug-induced arrhythmias.

Mitcheson JS.

Chem Res Toxicol. 2008 May;21(5):1005-10. doi: 10.1021/tx800035b. Epub 2008 May 1. Review.

PMID:
18447395
6.

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.

Gustina AS, Trudeau MC.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13082-7. doi: 10.1073/pnas.0900180106. Epub 2009 Jul 27.

7.

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia.

Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA.

Cell. 1999 Apr 16;97(2):175-87.

8.

The hERG potassium channel as a therapeutic target.

Witchel HJ.

Expert Opin Ther Targets. 2007 Mar;11(3):321-36. Review.

PMID:
17298291
9.

The Susceptibilities of Human Ether-à-Go-Go-Related Gene Channel with the G487R Mutation to Arrhythmogenic Factors.

Hisajima N, Hata Y, Kinoshita K, Fukushima T, Nishida N, Kano M, Tabata T.

Biol Pharm Bull. 2015;38(5):781-4. doi: 10.1248/bpb.b14-00630.

10.

Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation.

Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC.

J Biol Chem. 1999 Apr 9;274(15):10113-8.

11.

The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.

Ficker E, Obejero-Paz CA, Zhao S, Brown AM.

J Biol Chem. 2002 Feb 15;277(7):4989-98. Epub 2001 Dec 10.

12.
13.

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.

Stansfeld PJ, Sutcliffe MJ, Mitcheson JS.

Expert Opin Drug Metab Toxicol. 2006 Feb;2(1):81-94. Review.

PMID:
16863470
14.

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.

Ganapathi SB, Kester M, Elmslie KS.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C701-10. doi: 10.1152/ajpcell.00633.2008. Epub 2009 Feb 25.

15.

Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.

Pareja K, Chu E, Dodyk K, Richter K, Miller A.

Channels (Austin). 2013 Jan 1;7(1):23-33. doi: 10.4161/chan.22669. Epub 2012 Dec 6.

16.

Revealing the structural basis of action of hERG potassium channel activators and blockers.

Perry M, Sanguinetti M, Mitcheson J.

J Physiol. 2010 Sep 1;588(Pt 17):3157-67. doi: 10.1113/jphysiol.2010.194670. Epub 2010 Jul 19. Review.

17.

hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia.

Nogawa H, Kawai T.

Eur J Pharmacol. 2014 Oct 15;741:336-9. doi: 10.1016/j.ejphar.2014.06.044. Epub 2014 Jul 3. Review.

PMID:
24998878
18.

hERG channel function: beyond long QT.

Babcock JJ, Li M.

Acta Pharmacol Sin. 2013 Mar;34(3):329-35. doi: 10.1038/aps.2013.6. Review.

19.

Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel.

Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, Medina A, Zhang L, Wang Z.

Circulation. 2002 Feb 19;105(7):794-9.

20.

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

McPate MJ, Duncan RS, Witchel HJ, Hancox JC.

J Mol Cell Cardiol. 2006 Sep;41(3):563-6. Epub 2006 Jul 12.

PMID:
16842817

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